Wednesday, 17 September Finish Ch 11 Endocrine System Start Ch 6 Nervous System Psychology Seminar: Thursday, 11 am Dr. Steven St.John on “Salt Appetite” Examples of endocrine disorders Stress and cortisol Ch 6 Part A Basic terms Quiz on Monday (Endocrine Chapter & Endocrine Case Studies Lab)

Tropic hormones control the function Trophic hormones promote survival and growth of targets Releasing Hormone Release Inhibiting Hormone Long-loop negative feedback Short-loop Neg. Feed.

Symptoms of hypothyroidism Levels of TSH and TH? Explain enlarged thyroid gland Cause: Inadequate dietary intake of iodine Treatment? Endemic Goiter TRH TSH T3 & T4 Goiter Elevates basal metabolic rate, potentiates response to EPI

Age 16, 33, 52 No Relation!

Acromegaly Excessive growth of bones and soft tissues of face and hands, and feet. Hypersecretion of Growth Hormone from adenohypophysis or ectopic tumor Treatment? Transphenoidal resection/ablation with focal radiation Somatostatin analogs GH receptor blockers Compare to Pituitary Gigantism

⇧Cortisol secretion from Adrenal Cortex Mobilize fuel from muscle & adipose tissue Suppress non-essential functions (reproduction & growth) Suppress inflammatory & immune responses Potentiates response to EPI (vascular smooth muscle) ACTH from Ant. Pit CRH from Hypothalamus Physical trauma Prolonged exposure to cold Prolonged intense exercise Infection Sleep deprivation Pain Fright Emotional distress Vasopressin Cytokines from immune cells Excess Cortisol from 1) adrenal cortex tumor (primary) or 2) hypersecretion of ACTH from anterior pituitary (secondary) Cushing’s Syndrome

Endocrine disorders Hypersecretion –Primary –Secondary Hyposecretion –Primary –Secondary CRH ACTH Cortisol hypothalamus Anterior pituitary Adrenal Cortex

Lab Next Week Critically reading a Scientific Paper King et al., Effects of oral androstenedione on serum testosterone and adaptations to resistance training in young men. JAMA 281:

Questions so far?

Neurons? Endocrine cells? Neuroendocrine cells?

Endocrine System Nervous System Common features Major differences