The cell cycle Cytokinesis: cytoplasm divides Nucleus divides growth new protein and organelles made mitosis G1 Proteins needed for cell division made G2 S DNA replicates The cell cycle

Subject to copyright clearance a suitable image showing mitosis could be inserted here. e.g. one similar to that found at: http://www.microscopy-uk.org.uk/mag/imgaug99/whole.jpg

Cell at interphase Protein synthesis Organelle synthesis DNA replication Subject to copyright clearance a suitable image showing interphase could be inserted here. e.g. one similar to that found at: http://www.fed.cuhk.edu.hk/~johnson/photomicrographs/mitosis/animal/animal_interphase.htm

A single chromosome at the beginning of mitosis Has two chromatids as the DNA replicates during interphase before mitosis centromere

Early prophase centrioles nucleolus DNA coils and condenses Chromosomes take up stain

prophase Centrioles move apart Nuclear membrane breaks down Nucleolus fades Chromosomes continue to condense

Nucleolus disappears Chromosomes continue to condense

Nuclear membrane broken down metaphase Chromosomes aligned on the equator Nuclear membrane broken down Each chromosome attached to spindle fibre by the centromere

Anaphase Centromeres divide and chromatids pulled apart

Anaphase

anaphase

Anaphase Sister chromatids are pulled to opposite poles of the cell

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