制作人 张晓东 张晗晖 韩思奇 尹利国 梁婷婷 张莹 徐芳

Source Mechanism Function Diseases ( IDDM ) Therapy prospect catalogue

Source Helper T cells are found in two distinct cell types,Th1 and Th2,distinguished by the cytokines they produce and the immune responses they are involved in

Mechanism

CKs secreted by Th1 IFN-γ TNF- β IL-8 other Chemokines

Function CKs secreted by Th1 can activate and attract macrophage to the inflammatory location. IFN-γ inhibits the proliferation of Th2

CKs secreted by Th2 IL-4 IL-5 IL-6 IL-10 IL-13 IL-12

Function CKs secreted by Th2 play an important role in activation,differentiation,proliferation of B lymphocyte. IL-12 promoting activation of Th1. IL-10 inhibites Th1 secreting IFN-γ.

Diseases Autoimmune Diseases

Th1 predominant response diseases Insulin dependent diabetes mellitus(IDDM) Theumatoid arthritis Helicobacter pylori(HP) infection

Th2 predominant response diseases Systemic lupus eryhematosus Metal ion induced autoimmune diseases

Rheumatoid arthritis

Systemic lupus eryhematosus(SLE)

Therapy Anti-Th1 type cytokine therapy Anti-Th2 type cytokine therapy Other therapy for Th1/Th2 cytokine balance

Anti-Th1 type cytokines therapy and mechanism

Mechanism of insulin dependent diabetes mellitus Pancreatic islet βcell destroy insulin produced decrease DDM is mediated by Th1cell,which produce large amount of IFN-γ.it is imoportant in leading to diabetes

therapy Inject IFN-γ monoclonal antibody can turn Th1 to Th2,then cytokines L-4,L-10 expression increase to prevent diabetes

Th2 type cytokines therapy and mechanism

1.downstream APC 2. inhibit Th1 proliferation 3.inhibit L-1,TNF-2 and other cytokines(L-6,L-8) produced 4.inhibit matrix metal protein produce

Prevent diabetes of NOD mice I-A 27 allelic gene56,57 mutation produce Th2 cell of pancretic islet β cell antigen specificity T cell no response prevent the disease

Other therapy for Th1/Th2 cytokine balance (1)Mucosa tolerance: The TCR/CD3 complex of Th cell recognize MHC-peptide complex of APC,change TCR 、 antigen peptide and MHC (2)Nirogen monoxide(NO) downstream Th1cell and upstream Th2 cell decrease the apoptosis of Th2 cell

Prospect Regulate the ratio of Th1 and Th2 by medicine,we can cure some diseases without clearly known mechanisms.For example:SLE With the development of the immunology,we all expected these methods can be used to clinic, then these diseases will be cured.