30 patient drug sensitivity data Figure S1

Figure S2A Myeloid regulator enrichment in AML

Figure S2B Myeloid regulator enrichment in cALL

Figure S2C Myeloid regulator enrichment in CLL

Figure S2D Myeloid regulator enrichment in MDS

Figure S3A Malacards AML

Figure S3B Malacards cALL

Figure S3C Malacards CLL

Figure S3D Malacards MDS

Figure S4A CGC AML

Figure S4B CGC cALL

Figure S4C CGC CLL

Figure S4D CGC MDS

Figure S5

Figure S6

Figure S7

Figure S8 Apoptosis AML

Signal transduction Immune response Mitochondrial function Celluar cytoskeleton Heme biosynthesis Figure S9

BCL-2 BAX Known anti-apoptotic factors A key mitochondrial pro- apoptotic protein Ohtsuka et al (2004) PYCARD Apoptosis SER in AML A key mediator in apoptosis and inflammation Youle et al (2008) FIGURE S10

Figure S11

Figure S12

Figure S13

Figure S14