Chapter 14 Hallucinogenic Drugs. Mescaline Peyote cactus.

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Presentation transcript:

Chapter 14 Hallucinogenic Drugs

Mescaline Peyote cactus

Psilocybin Psilocybe mushrooms psilocybin  psilocin

LSD

Pharmacology of Hallucinogenic Drugs

LSD Trip (psychological effects) 1.Onset 2.Plateau 3.Peak 4.Come-down Pharmacology of Hallucinogenic Drugs

Physiological effects Activate sympathetic nervous system –Dilated pupils –Heart rate increase –Blood pressure increase –Body temperature increase Dizziness Nausea and vomiting Pharmacology of Hallucinogenic Drugs

Most hallucinogens are 5-HT receptor agonists If you use a 5-HT receptor antagonists together with a hallunicongen, illusions and hallucinations disappear Pharmacology of Hallucinogenic Drugs

Pharmacology of Hallucinogenic Drugs Acquisition of an LSD/saline discrimination and attenuation of the drug stimulus cue

Problems with hallucinogenic drugs “Bad Trip” Flashbacks Psychotic breakdown Pharmacology of Hallucinogenic Drugs

PCP Dissociative Anesthetics

Ketamine crystals Dissociative Anesthetics

PCP Self-administration of PCP into the nucleus accumbens shell by rats

Ketamine Ketamine administration produces a dose-dependent increase in psychotic- like symptoms