BSG Pathology Section Liver Slide Seminar, Birmingham, March Clinical Summaries - Stefan Hübscher Prof. Stefan Hubscher Case 1 Male, age 52. Recent onset of jaundice and abnormal LFTs. AST 793 (normal 5-43), ALP 655 (70-330), bilirubin 172 (1-22). ANA positive (1:100), SMA positive, IgG 19.5 (normal 6-16). Liver biopsy.

Case 2 Female, age 54 Potential donor liver retrieved from another centre in the UK Died from subarachnoid haemorrhage. No history of alcohol. Liver not used because of macroscopic appearance - generally fatty, atrophy of segment 5 in right lobe Wedge biopsies taken from left lobe, segment 5 and segment 6. Slide submitted is from left lobe biopsy.

Dr Judy Wyatt Case 3 Female, age 3 Developed ALL age 2½. Presented with acute veno-occlusive disease during 6TG treatment which settled with supportive treatment. Changed to 6MP. 1 year later, presented with haematemesis, due to bleeding oesophageal varicies. One year after that developed respiratory failure, requiring continuous oxygen. Diagnosis – hepatopulmonary syndrome. Liver transplant performed. Liver 520g, nodules up to 11mm.

Case 4 Male, age 48. Presented 2 years earlier with bleeding oesophageal varices. Diabetes 20 years, recently become insulin dependent. BMI 33. Liver transplant for cryptogenic cirrhosis.

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Prof Alastair Burt Case 5 Male, age 18. Cystic fibrosis, recurrent chest infection. Developed bleeding oesophageal varices. Some deterioration of general synthetic function. Underwent combined lung/liver transplantation – block from explant.

Case 6 Male, age 55 History of highgrade B cell non-Hodgkin’s lymphoma, treated with several rounds of chemotherapy. Liver function tests abnormal - underwent laparoscopic biopsy (large wedge specimen). Clinical diagnosis = hepatic involvement by lymphoma.

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