Awake Animal SPECT: Overview and Initial Results O AK R IDGE N ATIONAL LABORATORY U.S. DEPARTMENT OF ENERGY Drew Weisenberger 1, Brian Kross 1, Stan Majewski 1, John McKisson 1, Vladimir Popov 1, James Proffitt 1, Sasha Stolin 1, Justin Baba 2, Jim Goddard 2, Mark Smith 4,Ben Tsui 3 and Martin Pomper 3 1 Thomas Jefferson National Accelerator Facility, 2 Oak Ridge National Laboratory, 3 Johns Hopkins University, 4 University of Maryland.

SPECT camera Infrared Tracking System Awake Animal SPECT-CT Imaging System An awake mouse with infrared reflectors for head tracking shown in imaging burrow. Computer display illustrating real-time pose tracking via the stereo infrared CCD cameras.

SPECT camera SPECT camera data and voltage cables Accommodate analog signals from two gamma camerasAccommodate analog signals from two gamma cameras Need to incorporate time stamp event by eventNeed to incorporate time stamp event by event Software controlled high voltage to gamma camerasSoftware controlled high voltage to gamma cameras Elimination of long signal wires by employing fiber optic USB2 repeaterElimination of long signal wires by employing fiber optic USB2 repeater SPECT Data Acquisition System Modifications

SPECT cameras JLab FPGA data acquisition system USB-fiber optic Infrared Tracking System mouse in burrow

Tc99m-MDP SPECT Scan of Awake Mouse Movie of Multiple SPECT Projections