Immunotherapies to Fight Cancer August 2015

2 01 RADIATION 02 SURGERY Pillars of Cancer Treatment An overview of cancer therapies 03 CHEMOTHERAP Y 04 IMMUNOTHERAPY

MICROENVIRON CAR-T CELLS

4 Rings Not Genes Existing CAR-T TechnologiesNon-Genetic Biology Faster. Safer. Cheaper.

5 Status of Tychon Technology Clinical CandidatesInvivo StudyResults PSMA CD-19 Q3 2016

6 Tychon Current Fundings SERIES A * Currently raised ** Amount depends on strength of current animal study SEED ROUND $30M ** to $10M$1.5M *

7 CAR-T Therapy Chimeric Antigen Receptor Modified T-Cells 01 LEUKAPHERESIS 02 SELECTION & ACTIVATION 04 CELL EXPANSION 03 GENE TRANSFER 05 INFUSION

Partnership Landscape 8

9 Carston Rick Wagner, Ph.D. Professor Chair of Medicinal Chemistry Endowed Chair of Medicinal Chemistry Director, Chemical Biology Initiative, U of M Tychon Bioscience, LLC Danny Cunagin Co-Founder & CEO, Invensure, LLC Founder, Chairman of Board Exosite Chairman of the Board, Imbio, LLC Management Consultant, Asombro Troy Kopischke Co-Founder & CEO, Invensure, LLC Co-Founder & CEO, OneOme Co-Founder, Board Member Exosite President / CFO, Imbio, LLC Management Team

10 In Girls Last Hope, Altered Immune Cells Beat Leukemia New York Times Dec. 9, 2012 Desperate to save her, her parents sought an experimental treatment at the Children’s Hospital of Philadelphia, one that had never before been tried in a child, or in anyone with the type of leukemia Emma had. The experiment, in April, used a disabled form of the virus that causes AIDS to reprogram Emma’s immune system genetically to kill cancer cells. The treatment very nearly killed her. But she emerged from it cancer-free, and about seven months later is still in complete remission. She is the first child and one of the first humans ever in whom new techniques have achieved a long-sought goal — giving a patient’s own immune system the lasting ability to fight cancer. The Promise of Adoptive T-Cell Therapy

11 Contact Us For More Information OFFICE 227 Colfax Avenue North Suite 148 Minneapolis, MN PHONE / WEBSITE

12 Healing is a matter of time, but it is sometimes also a matter of opportunity. Hippocrates EpCam: Breast, Colon Cancer CD22 & CD19: B-cell Leukemias EGFR: Ovarian, Brain Cancer PSMA: Prostate, Brain Cancer DR5: Pancreatic and Prostate Cancer CD133 & EpCam: Cancer Ctem Cells CD16: PAR-Nkcells CSANs Based Vaccines PET & MRI Cell Imaging Our Current Focus