Life Sciences Luxembourg Centre for Systems Biomedicine UL evaluation 2012 Life Sciences Luxembourg Centre for Systems Biomedicine (LCSB) rudi.balling@uni.lu 17th February 2012 4/25/2017

LCSB: An Interdisciplinary Centre within the University Language Literature Humanitites Arts Education (FLSHASE) Systems Biomedicine (LCSB) Science Technology Communication (FSTC) Law Economics Finance (FDET) Security, Reliability, Trust (SNT) Faculties Interdisciplinary Centres

LCSB: The First 2 Years September 2009 September 2011

Luxembourg Centre for Systems Biomedicine (LCSB) Experimental Biology Computational Biology LCSB Technical Platforms Clinical Research

The interdisciplinary nature of the LCSB Technology Theory Transcriptomics Proteomics Metabolomics Bioinformatics Computational Biology Modelling and Simulation Animal Models Human Genetics Public Health Parkinson`s Disease Chemical Biology Imaging Experimental Biomedicine Gene-Environment Interactions Experiments 4/25/2017

Network models of diseases: Inference and analysis Thematic focus Computer Cells Mice Patients Families Network models of diseases: Inference and analysis

Thematic focus Parkinson´s Disease Genetics & Genomics Mol.- & Cellular Biology Computational Biology Clinical Translation

Thematic focus The LCSB Parkinson's Disease Research Program Nico Diederich Paul Antony Mitochondrial dysfunction in PD patients Metabolome analysis of PD-patients Clinical PD projects Karsten Hiller Sequencing of PD patients David Galas/ISB DJ-1, PINK-1, a-Synuclein mouse models of PD Manuel Buttini The LCSB Parkinson's Disease Research Program PD-network analysis in SH-SY5Y cells Paul Antony Patrick May Animal and Cellular Models of PD Neuron-Astrocyte-Microglia Crosstalk Alessandro Michelucci iPS-cells from PD-patients Lasse Sinkkonen Comparative Human-Mouse Systems Analysis Antonio del Sol Avrind Tallam Computational Models of PD A PD-SBGN-map SBI & LCSB A kinetic model of PD related ROS generation Alexey Kolodkin

Organisational structure: Research groups Experimental Biology (Sept 2009) Endocrinology (February 2011) Metabolomics (Sept 20010) Bioinformatics (April 2011) Eco-Systems Biology (October 2011) Computational Biology (February 2010) Machine Learning (November 2010) 4/25/2017

Bioinformatics and Computational Biology Reinhard Schneider Antonio del Sol Nikos Vlassis

Organisational Structure: Translational Research Jochen Schneider 20 % Clinic 80 % LCSB Nico Diederich 90 % Clinic (CHL) 10 % LCSB Carine de Beaufort 75 % Clinic (CHL) 25 % LCSB

Experimental Models of Parkinson´s disease

Eco-Systemsbiology in the Gut

Technology Focus: Metabolomics LPS The Karsten Hiller-Team Alessandro Michelucci 4/25/2017

LCSB: The Integration within the UL Professorships Projects Personnel Teaching Infrastructure Projects Students IT infrastructure LSRU LCSB CSC Link to LSRU, CSC, Doctoral school We have joint grants UL Joints AFR grants Joint student ships Joint projects CSC Doctoral School LCSB and LSRU PhD students

LCSB: The National Collaborations The Personalised Medicine Consortium Patients Clinical Studies Sample - collection - processing - storage Metabolomics Imaging Bioinformatics Computational Biology Proteomics Clinical Trial Centre

Personalized Medicine Consortium (PMC) Parkinson Disease Team Diabetes Disease Team Cancer Disease Team In each team: 2-3 clinicians and 2-3 basic scientists Nico Diederich Rudi Balling Carine de Beaufort Jochen Schneider Guy Berchem Bruno Domon Team Leaders Marek Ostaszewski tbd tbd Project Manager

LCSB: The International Collaborations Systems Biology (ISB-Seattle) Microfluidics (Univ.-Arizona) PD-Disease Map (Kitano-Tokyo) Mouse Models (HMGU-Munich) Metabolic Networks (MIT-Boston)

LCSB: The challenges Develop a competitive Parkinson´s Disease research programme 1 Develop a bioinformatics and computational biology core 2 Establish appropriate infrastructure and technology platforms 3 Develop an attractive PhD-programme in Systems Biomedicine 4 Establish LCSB as an attractor for industrial cooperations 5