Brenda Poulter International Applications Specialist Thailand November 2004

Agenda Overview of SciFinder Content –Databases –Currency Search Examples –Topic –Author –Structure Additional topics and Hands on practice

Databases of SciFinder CAplus CASREACT CHEMCATS CHEMLIST MEDLINE/OLD MEDLINE REGISTRY

CAplus A CAS literature database containing references to research published in journals, patents, and other sources Contains Bibliographic, Abstract and Indexing Information – all searchable 1907 to present (some 1800’s) Over 23,650,000 records Updated daily

Medline/Old Medline A literature database containing references to Medical research published in journals Contains Bibliographic, Abstract and Indexing Information – all searchable 1953 to present About 14,500,00 references Updated 4 times per week

Registry Substance Database containing CAS RN, Structures, Chemical Names, Properties, Sequences 1957 to present Over 73 Million substances

CASREACT Database of Reactions 1840 to present 8,517,229 Single- and multi-step reactions Search full or half reactions Search Reactants, Reagents, Products, catalysts, any Role

CHEMCATS Quickly and easily obtain current information on commercially available chemicals and their worldwide suppliers More than 8.1 million products –734 suppliers –834 catalogs Updated upon receipt of new catalog

CHEMLIST Regulatory information from 19 Government Regulatory lists around the world 235,034 Inventoried/regulated substances Updated Weekly

Sources of SciFinder Over 9,000 journals monitored Patents (50 patent organizations) Technical disclosures Conference proceedings Technical reports Books Dissertations Reviews Meeting abstracts Web preprints IP.com Journal Electronic-only journals etc

Currency of SciFinder Updated Daily 1829 Core Journals (over 9000 total) –Bib and abs data within 5 days of receipt –Fully indexed within days 7 core patent organizations (50 total) –Bib and abs data within 2 days of publication –Fully indexed within 27 days

SciFinder Improves the Process

SciFinder Saves Time

SciFinder Provides Current Information

SciFinder Exposes New Research

SciFinder Makes Searching Easy

Explore Topics

Searching by Company/Organization

Chiang Mai Search Results

Limitation by Author

Analysis by topics of Interest

Index term analysis

Get Related Information

Get Related feature Starting your search from a text explore Obtain all the substances indexed in the reference list –Answer set must be <1000 references –Refine with structure fragments or calculated properties Obtain the older cited references or forward citing references –Answer set must be <500 references

Citation searching The CAplus database includes citations from journal and patent references –Only from 1998-present 1997 is in progress –From roman script sources –Over 100 million citations Older references can be searched as citing references –Results limited to 1998-present

Author Search

Author Candidates

Full Text Patent

Citing References

Analysis of those who referenced paper

Better substance searching Pharmaceutical compounds are seldom simple neutral compounds Beware that salts and mixtures may have their own CAS Registry number Better to search known compound as an exact structure that as a name –Includes different stereoisomers, salts and mixtures Can copy/paste a CAS Registry to import the structure

Explore by Structure Search

Additional options allow for The inclusion or exclusion of Certain substance classes.

Explore by Structure Search

Analyze and Refine

Analyze features

Analyze Features

Refine Substances

Explore by Structure Search

Styrene-Isoprene polymers

With additional components: 573 Not possible to limit the maximum number of components

Without addl. components: 22 May include some oligomers and radio- labeled compounds

Searching by MF For addition polymers and most condensation polymers put the molecular formula of the monomers, separated by dots, within brackets and close with an “X” –(C8H8)x for styrene homopolymer –(C8H8. C5H8)x for styrene-isoprene polymers For structural repeating units of symmetric condensation polymers put the formula of the repeating unit within brackets and close with an “N” –(C14H12O4)n for polybutylene terephthalate –(C2H4O)nCH4O for  -methyl-  -hydroxy PE

Results for (C8H8. C5H8)x

Coordination Compounds Molecular Weight Easily search coordination compounds with either a molecular weight or a structure.

Coordination Compounds Structure and Refinement The additional options button allows for refinement of answers prior to the search.

References to Related Structures

Reaction Searching

Limiting Reaction Results

Reaction Results Screen

Retro Synthesis and Additional Information

Reaction Searching with functional Groups

Reactions Containing Phenol

View Change of Reaction Answers Reaction view may be changed. View / One reaction per reference.

Grouped Reaction Answer Reactions may be viewed as one representative reaction per reference. To see all reactions in the reference, click on link

Searching by substance name

Behind the Research Topic Explore feature Takes natural language query and search concepts in CAplus and Medline Concepts are identified using the natural adjectives and filler words Concepts are checked for chemical names –Searched both as name and as CAS RN Various combinations of terms as candidates –Exact phrase for a simple question –Terms closely associated in the text (same sentence) –Terms anywhere in the text (same document)

How to add synonyms SciFinder includes many different word spellings, abbreviations and many synonyms –Not comprehensive ; please consult your answers for terms not highlighted in blue Use brackets to indicate a synonym to a particular concept –E.g., drug analysis (pharmaceutical analysis) –Could use “OR” in simple cases

More Research Topic features Can use a CAS Registry Number in a natural phrase Can use words to exclude a concept –Refine by research topic can even start with a NOT operator Use quotes to find words as entered Use WITH when “anding” a list May use AND when searching There are limits to the complexity of your search statement

Topic Search of Liver fluke

Refining by Thailand References

Limit by Thailand

Topic searching using WITH

Getting Related Substances

Substances found within papers

Refine by Structure

Browse Table of Contents

ChemPort