Ion Channels as pores…... High capacitance of the PL bilayer is attributed to the small length of the H-C chains (space between the parallel plates).

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Presentation transcript:

Ion Channels as pores…..

High capacitance of the PL bilayer is attributed to the small length of the H-C chains (space between the parallel plates).

Basic Electricity to Understand Biological Signals

The outer shell – loss or gain of electrons is the foundation of Electronic Theory What are the analogous biological membrane components for a basic circuit?

Electron Theory Positive to Negative is the convention attributed to Ben Franklin, yet is not reality

Ohm’s Law is most widely used physical law in electrophysiology

Which is the biological circuit? Why?

The Membrane As a Capacitor

How does the capacitance affect the voltage response? How do you calculate capacitance? How can capacitance determine size of the cell?

Potential difference driven by ion composition and ATPase pumps

The Nernst Equation

The Goldman Equation

What Do Current Voltage Relationships Tell us about Selectivity and Ion Channel Properties?

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