Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light.

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Presentation transcript:

Immunoglobulin Isotypes Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chains

Immunoglobulin Isotypes Occurrence Importance Ig levels Definition Location IgM (kappa) IgG1 (kappa)

Immunoglobulin Allotypes Definition - Antigenic determinants specified by allelic forms of the Ig genes Location Occurrence – Source of anti- allotypic Abs IgG1 (kappa) Person 2 IgG1 (kappa) Person 1

Human Immunoglobulin Allotypes Nomenclature – G1m(3) – Km(1) - G2m(23)

Human Immunoglobulin Allotypes IgG – 25 Allotypes IgA2 – 2 Allotypes k (L) – 3 Allotypes

Immunoglobulin Idiotypes Definition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificity

Immunoglobulin Idiotypes Definition Location IgG1 (kappa) Person 1 anti-B IgG1 (kappa) Person 1 anti-A

Immunoglobulin Idiotypes Definition Location Importance V region marker Regulation of immune responses

Immunoglobulin Idiotypes Definition Location Importance V region marker Regulation of immune responses Vaccines

AgIdanti-Id + - Anti-Idiotype Vaccines AgIdanti-Id +

Anti-Idiotype Vaccines Ag + Ab Ag / Ab + Ab = Ag Anti-Id-Ab Vaccine

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