Local Vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury by Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa.

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Local Vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury by Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa Lee, Tsui-Yu Mok, and Kai-Ming Chan J Bone Joint Surg Am Volume 95(7):e41 April 3, 2013 ©2013 by The Journal of Bone and Joint Surgery, Inc.

A decrease in the level of the reduced form of glutathione (GSH) at two and six weeks postinjury and an increase in the level of oxidized glutathione (GSSG) at six weeks postinjury, compared with the levels in the intact tendon, suggested the presence of ox... Leung-Kim Hung et al. J Bone Joint Surg Am 2013;95:e41 ©2013 by The Journal of Bone and Joint Surgery, Inc.

The maximum flexion angle of the proximal interphalangeal joint and the gliding resistance were calculated to evaluate the extent of restrictive tendon adhesion. Leung-Kim Hung et al. J Bone Joint Surg Am 2013;95:e41 ©2013 by The Journal of Bone and Joint Surgery, Inc.

The cross-sectional area of the flexor tendons (flexor digitorum superficialis and flexor digitorum profundus [FDS+FDP]) at the injured site was measured with 3-D ultrasound imaging to evaluate the magnitude of fibrosis. Leung-Kim Hung et al. J Bone Joint Surg Am 2013;95:e41 ©2013 by The Journal of Bone and Joint Surgery, Inc.

Histological sections at two weeks postinjury reveal tendon swelling at the injured site in both the saline solution (Fig. 4-A) and the 5-mg/mL vitamin-C (Fig. 4-B) group. Leung-Kim Hung et al. J Bone Joint Surg Am 2013;95:e41 ©2013 by The Journal of Bone and Joint Surgery, Inc.