Cure of Colitis by CD4 + CD25 + Regulatory T Cells Barrette Kathleen – Dreesen Erwin Mottet C, Uhlig HH, Powrie F.

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Presentation transcript:

Cure of Colitis by CD4 + CD25 + Regulatory T Cells Barrette Kathleen – Dreesen Erwin Mottet C, Uhlig HH, Powrie F

CD4 + CD45RB low CD45RB high CD4 - CD25 + CD25 -

CD4 + CD45RB low CD45RB high CD4 - CD25 + CD25 - Regulatory T cells (T reg ) As therapeutic agents?

Conditions -Inhibit ongoing T cell responses -Reverse established pathology

Experimental protocol

CD4 + CD25 + T R cells reverse wasting disease

CD4 + CD25 + T R cells reverse colitis

CD4 + CD25 + T R cells reverse wasting disease & colitis

CD4 + CD25 + T cells home to the MLN & colon * P < 0,05 *

CD4 + CD25 + T cells home to the MLN & colon

The progeny of CD4 + CD25 + T cells proliferate in MLN & colon

CD4 + CD25 + T cells are in contact with CD11c + cells and CD4 + T cells in vivo