How willing are gay men to “cut off” the epidemic? Circumcision among MSM in the Andean region Guanira J 1, Lama JR 1, Goicochea P 1, Segura P 1, Montoya.

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Presentation transcript:

How willing are gay men to “cut off” the epidemic? Circumcision among MSM in the Andean region Guanira J 1, Lama JR 1, Goicochea P 1, Segura P 1, Montoya O 2, Sánchez J 1 1Asocicion Civil Impacta Salud y Educación, Lima, Perú, 2Fundacion Ecuatoriana Equidad, Guayaquil, Ecuador

Background HIV epidemic in the Andean region is concentrated in men who have sex with men (MSM) HIV epidemic in the Andean region is concentrated in men who have sex with men (MSM) Cases continue to increase despite the broadly known preventive strategies Cases continue to increase despite the broadly known preventive strategies Male circumcision studies have proven to be efficacious in reducing HIV acquisition in heterosexual men by 60%. Male circumcision studies have proven to be efficacious in reducing HIV acquisition in heterosexual men by 60%. Differences in vaginal vs. anal mucosa, and types of sexual roles might compromise the effectiveness of this intervention in MSM. Differences in vaginal vs. anal mucosa, and types of sexual roles might compromise the effectiveness of this intervention in MSM. Formative research is of need to assess the feasibility of the implementation of such a study in the MSM population Formative research is of need to assess the feasibility of the implementation of such a study in the MSM population

Objectives To assess circumcision rates in MSM To assess circumcision rates in MSM To evaluate the willingness to participate in a circumcision trial for HIV prevention among MSM To evaluate the willingness to participate in a circumcision trial for HIV prevention among MSM To identify concerns, barriers and facilitators for the implementation of a circumcision trial in MSM To identify concerns, barriers and facilitators for the implementation of a circumcision trial in MSM

Design Study design Cross sectional study Inclusion criteria: Anal sex within the last 12 months Unknown or HIV (-) status and not having an HIV test during the previous 12 months High risk behavior Procedures Clinical history Physical examination, Behavioral assessment (Computer Assisted Self Interview, CASI) Testing for HIV-1/2 and syphilis

2618 MSM at high risk for HIV infection enrolled. Peru: Lima (676), Arequipa (417) and Ica (414) Ecuador: Guayaquil (541) HIV Sentinel surveillance among high risk MSM in five Andean cities 570 from Sullana & Piura were excluded for this analysis due to issues in circumcision status assessment Circumcised (75)Uncircumcised (1932) Willingness to participate in a circumcision trial questionnaire 41 participants refused to be examined Lima Ica Arequipa Guayaquil

Demographic and behavioral characteristics LimaArequipaIcaGuayaquilTotal N Age (mean, (SD)) (7.2)26.30 (8.3)25.93 (7.2)26.61 (7.8)26.34 (7.6) Education Less than high school 12 (1.9)2 (0.5)12 (3.0)44 (8.5)70 (3.6) High school 351 (55.0)265(67.4)239 (59.6)321(61.7)1176 (60.3) More than high school 275 (43.1)126 (32.1)150 (37.4)155 (29.8)706 (36.2) Monthly Income ($) No income 144 (22.8)138 (33.1)105 (25.4)137 (26.6)524 (26.8) > (22.0)82 (20.6)115 (28.3)46 (8.9)382 (19.6) (32.5)138 (34.6)140 (34.4)137 (26.6)620 (31.8) (13.3)25 (6.3)29 (7.1)102 (19.8)240 (12.3) (9.4)16 (4.0)18 (4.4)93 (18.1)186 (9.5) Sexual Role in the last 5 years Exclusively Insertive 195 (30.1) 231 (57.8)197 (48.9) 167 (32.9)790 (40.3) Mainly Insertive 75 (11.6) 33 (8.3)15 (3.7) 35 (6.9)158 (8.1) Half time insertive 142 (21.9)47 (11.8)47 (11.7)149 (29.2)385 (19.6) Mainly receptive 116 (17.9) 26 (6.5)36 (8.9) 49 (7.8)218 (11.1) Exclusively receptive 120 (18.5) 63 (15.8)108 (26.8) 120 (23.5)411 (21.0)

Early syphilis, HIV rates, and HIV estimated incidence

Circumcision rates by city

Willingness to participate in a CT among those not circumcised OR (95% CI) AOR Age (per 10 years) Education Less than High school 1-1- High school More than high school Monthly income ($) No income 1-1- > Sexual Role in the last 5 years Insertive* Receptive1-1- City Lima1-1- Arequipa Ica Guayaquil *Insertive: Those reporting being insertive at least 50% of the time in the last 5 years (exclusively, mainly and half of the time)

Major concerns of participation in a circumcision trial among those willing

Discussion MSM at high risk in the Andean region have high rates of HIV and STI MSM at high risk in the Andean region have high rates of HIV and STI Circumcision rates in MSM are low across all study cities Circumcision rates in MSM are low across all study cities No association between circumcision and HIV infection when all the sample is included. A trend to a significant protective effect is seen when only “insertive” are analyzed. No association between circumcision and HIV infection when all the sample is included. A trend to a significant protective effect is seen when only “insertive” are analyzed. Higher education and living in large cities are independently associated to be willing to participate in a circumcision trial for HIV prevention in MSM Higher education and living in large cities are independently associated to be willing to participate in a circumcision trial for HIV prevention in MSM Major concerns of undergoing circumcision are related to surgical procedure and misperception of protection Major concerns of undergoing circumcision are related to surgical procedure and misperception of protection

Limitations Design limitations: Design limitations: Convenience based samples Convenience based samples Self-selection bias Self-selection bias Recall bias Recall bias Low rates of circumcision in the sample decreased the power to find associations between circumcision and HIV infection Low rates of circumcision in the sample decreased the power to find associations between circumcision and HIV infection The results cannot be generalized The results cannot be generalized

Conclusions A circumcision study to assess its efficacy in the prevention of HIV is feasible in the MSM population of Lima and Guayaquil A circumcision study to assess its efficacy in the prevention of HIV is feasible in the MSM population of Lima and Guayaquil

Acknowledgments Site coordinators Site coordinators Victoria Zamalloa Victoria Zamalloa Orlando Montoya Orlando Montoya Anabeli Tataje Anabeli Tataje Nora Ojeda Nora Ojeda Carmela Ganoza and the Impacta Lab team Carmela Ganoza and the Impacta Lab team Recruitment teams at each city Recruitment teams at each city Westat Team Westat Team US NIH/NIAID/DAIDS US NIH/NIAID/DAIDS Specially to study participants Specially to study participants Sponsored by: Comprehensive International Program for Research on AIDS (CIPRA) Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Grant Number: 1 U19 AI A2 DAIDS Protocol Number: CIPRA PE 002