Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Neoplasia VI DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Biology of tumor growth. Kinetics of tumor cell growth. Tumor angiogenesis. Tumor progression and heterogeneity. Tumor invasion and spread.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Doubling time : equal or more than that of normal cells. Growth fraction : cells in replicative pool, rarely >20%. Production vz loss :
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Angiogenesis Tumor-associated angiogenic factors : -bFGF, VEGF …… etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin, thrombospondin ( p53 upregulated).
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Kinetics Of Tumor Cell Growth Clinical implications: 1- cancer therapey : Targeting cycling cells. Effect of radiation & debulking. 2- latent period of tumors : Months to years.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Progression and Heterogeneity.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Tumor Invasion and Spread. Methods of spread : - Direct. -Through blood vessels. -Through lymph vessels.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Etiology of Cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens.
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemical Carcinogens
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH
Neoplasia VI DR OSAMA I NASSIF FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY, KAUH Chemotherapy Induced Malignancies