Slides last updated: March 2015 CRC: RISK FACTORS.

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Presentation transcript:

Slides last updated: March 2015 CRC: RISK FACTORS

Lifestyle-related risk factors in CRC 1,2 Diets that are high in red meats and processed meats -Conversely, diets that are high in vegetables, fruits and whole grains have been linked with a decreased risk of CRC Physical inactivity Obesity/high body mass index Long-term smoking Heavy use of alcohol 1.American Cancer Society. Colorectal Cancer Detailed Guide, Available online from last accessed on 17/03/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines on Colon Cancer. Version Available online from last accessed on 17/03/2015.

Personal and family history-related risk factors in CRC 1,2 Personal history of CRC or adenomas Personal history of inflammatory bowel disease Family history of CRC or adenomas -Screening for CRC before the age of 50 may be an option Inherited syndromes -5-10% of CRC patients have inherited gene mutations -Includes familial adenomatous polyposis (FAP), hereditary non- polyposis colon cancer (HNPCC, or Lynch syndrome), Turcot syndrome, Peutz-Jeghers syndrome and MUTYH-associated polyposis 1.American Cancer Society. Colorectal Cancer Detailed Guide, Available online from last accessed on 17/03/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines on Colon Cancer. Version Available online from last accessed on 17/03/ Migliore L, et al. J Biomed Biotechnol 2011;Article ID The majority of CRC cases are sporadic; only 25% of CRC cases have a family history 3

Other risk factors in CRC 1,2 Age -90% of people diagnosed with CRC are ≥50 years old Type 2 diabetes Metabolic syndrome -Combination of diabetes, high blood pressure and obesity Certain racial and ethnic backgrounds -African-Americans have the highest CRC rates in the US -Ashkenazi Jews (of Eastern European descent) have one of the highest CRC risks of any ethnic group in the world; several gene mutations associated with CRC risk have been found within this group 1.American Cancer Society. Colorectal Cancer Detailed Guide, Available online from last accessed on 17/03/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines on Colon Cancer. Version Available online from last accessed on 17/03/2015.