Individual CB6 F1 mice develop multiple morbidities Histopathology at death from 52 animals, aged 24-32 months Number of lesions Number of Diseases % of.

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Individual CB6 F1 mice develop multiple morbidities Histopathology at death from 52 animals, aged months Number of lesions Number of Diseases % of individuals Mice with multiple morbidities Diseases in this pool of CB6 F1 mice

J. Exp. Med 210:2223 (2013) Note: This paper is from intramural researchers at NIA and NCI

In ischemia / reperfusion, two different treatments (sevoflurane and a GSK3  agonist) work in young but not in old Aged mice respond differently to interventions Li H et al. – Acta Anaesthesiol Scand 57:1024 (2013) YO - + Infarct Size Sevoflurane Zhu J et al. – Am J Physsiol Circ Physiol 300:H922 (2011) SB GSK3  agonist

Smith MA & French AM Psychopharmacology 162:255 (2002) Montalvo-Ortiz et al. PNeuropsychopharmacology 39: 1469 (2014)