Types of Cellular Networks. Gene Regulatory Networks

Slides:



Advertisements
Similar presentations
Cellular Networks.
Advertisements

Ch 18 Gene Regulation. Consider: A multicellular organism (Pliny) Do each of his cells have the same genes? Yes, with an exception: germ cells are haploid.
20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY? WHAT WOULD HAPPEN IF THEY WERE EXPRESSED.
13 The Genetics of Viruses and Prokaryotes. 13 The Genetics of Viruses and Prokaryotes 13.1 How Do Viruses Reproduce and Transmit Genes? 13.2 How Is Gene.
CHAPTER 8 Metabolic Respiration Overview of Regulation Most genes encode proteins, and most proteins are enzymes. The expression of such a gene can be.
AP Biology Chapter 18: Gene Regulation. Regulation of Gene Expression Important for cellular control and differentiation. Understanding “expression” is.
The Chapter 15 Homework is due on Wednesday, February 4 th at 11:59 pm.
Differentiation Cell & Molecular Biology. Genetic Control All cells in the body have the same genetic information Not all cells are identical. Cellular.
Lecture 14: Regulation of Proteins 1: Allosteric Control of ATCase
Bacterial Physiology (Micr430) Lecture 13 Regulation of Gene Expression (Text Chapter: 6) (Moat book)
Summary of Metabolism.
Biological networks Tutorial 12. Protein-Protein interactions –STRING Protein and genetic interactions –BioGRID Signaling pathways –SPIKE Network visualization.
Introduction to Metabolism __________ in nature – many reaction pathways the same or similar in many organisms Two general categories of organisms –_________.
Regulation of Gene Expression. Prokaryotes –Constituitive Gene Expression (promoters) –Regulating Metabolism (promoters and operators) –Regulating Development.
Software Development for Systems Biology Herbert M Sauro Frank Bergmann Keck Graduate Institute 535 Watson Drive Claremont, CA,
ANOVA WTdZAP1 p < /6189 (31.42%)2264/6189 (36.58%) p < /6189 (24.67%)1445/6189 (23.35%) p < /6189 (13.90%)792/6189 (12.80%) p
Modeling Functional Genomics Datasets CVM Lessons 4&5 10 July 2007Bindu Nanduri.
Metabolic Reactions Enzymology Catabolism Litho/Phototrophy Anabolism Microbial Metabolism.
Gene Regulation 8/24/2015. DNA Binding Proteins Histones Sequence specific DNA major grove Homodimeric Inverted repeats 8/24/2015.
In-Text Art, Ch. 9, p In-Text Art, Ch. 3, p. 37.
Review of Ondex Bernice Rogowitz G2P Visualization and Visual Analytics Team March 18, 2010.
Biological systems and pathway analysis An introduction.
Gene Regulation, Part 1 Lecture 15 Fall Metabolic Control in Bacteria Regulate enzymes already present –Feedback Inhibition –Fast response Control.
 We have discussed the concept that all genes for an organism are found in all cells that contain a nucleus ◦ But, only the proteins for that cell are.
Section 2 CHAPTER 10. PROTEIN SYNTHESIS IN PROKARYOTES Both prokaryotic and eukaryotic cells are able to regulate which genes are expressed and which.
CellDesigner and Virtual Cell Leang Chhun and Chanchala Kaddi Georgia Institute of Technology 29 June, 2006.
The ERATO Systems Biology Workbench: Enabling Interaction and Exchange Between Tools for Computational Biology Michael Hucka, Andrew Finney, Herbert Sauro,
How Does A Cell Know? Which Gene To Express Which Gene To Express& Which Gene Should Stay Silent? Which Gene Should Stay Silent?
Quiz #4/5. #4: Glycolysis (Tuesday, Feb 20 th ) #5: TCA cycle (Monday, Mar 5 th ) Pathways are in the books Quiz will have the entire pathway: –All cofactors.
Herbert Sauro, Michael Hucka, Andrew Finney,Hamid Bolouri Principal Investigators: John Doyle, Hiroaki Kitano JST/ERATO Kitano Systems Biology Project.
Chapter 10 Opener. Figure 10.1 Metabolic Diseases and Enzymes.
Biological systems and pathway analysis
Prokaryotes vs Eukaryotes
Control of Gene Expression Chapter 16. Contolling Gene Expression What does that mean? Regulating which genes are being expressed  transcribed/translated.
Jobs, Careers, Internships, Senior Projects and Research Computer Application Development K-12 education Industrial Training Bioinformatics Validation.
Supplemental Figure 2. IPA Gene Network Analysis. The top gene networks for DEGS more highly expressed (Panels A- B) and less highly expressed (Panels.
CHAPTER 18  REGULATION OF GENE EXPRESSION 18.1  Bacterial regulation I. Intro A. Genes are controlled by an on/off “switch ” 1. If on, the genes can.
General Microbiology (MICR300) Lecture 6 Microbial Physiology (Text Chapters: 3; 4.14; 4.16 and )
Gene Expression Chapter 16. DNA regulatory sequence All on DNA Promoters – Start transcription Promoters – Start transcription Terminators – End Transcription.
Characteristics of Sugar Binding Sites of Enzymatic Proteins
Control of Gene Expression
Cell Designer Sarah Killcoyne.
Control of Gene Expression
Regulation of Gene Expression
Cancer, reproductive system diseases, lipid metabolism 48 22
Human Cells Metabolic pathways
Regulation of Gene Expression
Unit 1 & 2 past paper questions
Regulation of Gene Expression
11/17/2018 Time Hierarchy is Important in Control! Relaxation Times of Different Cellular Processes First focus on time processes for enzyme activity or.
محاضرة عامة التقنيات الحيوية (هندسة الجينات .. مبادئ وتطبيقات)
Daily Warm-Up Tuesday, Jan. 7th
Cell Signaling.
Physics-based simulation for visual computing applications
DNA structure and gene expression
Gen Expression Constitutive Enzymes not Regulated
Introduction to Gene Expression
Patterns of control of gene expression
Regulation of Gene Expression
Significance Table from Anova Test
Characteristics of Life
Claudia Sala, David C. Grainger, Stewart T. Cole  Cell Host & Microbe 
Review Warm-Up What is the Central Dogma?
Unit III Information Essential to Life Processes
Characteristics of Life
Percentages of specific p-value data
Gene Regulation in Prokaryotes
Chapter 18 Bacterial Regulation of Gene Expression
Prokaryotic (Bacterial) Gene Regulation
III. Enzymes.
Presentation transcript:

Types of Cellular Networks

Gene Regulatory Networks

Gene Regulatory Network Basic Operations

Protein Signaling Networks

Protein Signaling Networks Basic Operations

Metabolic Networks

Some Characteristics NetworkSpeedPurpose‘Technology’ GeneSlow to medium Remodeling signaling and metabolic networks DNA binding to control expression ProteinMedium to fastSignal processingProtein covalent modification and sequestration MetabolicFastManufacturing, energy systems Enzymes, allosteric control

Software for Network Visualization Does not include ball-stick networks, eg cytoscape

Gene Regulatory Networks Biotapestry.org BioTapestry Cross-platform, Java, Open Source, SBML?, no simulation

Metabolic and Protein Networks JDesigner Windows, Delphi, open source SBML, Part of SBW

Gene Protein and Metabolic Networks TinkerCell tinkercell.com Cross-platform, Open source, C/C++, Qt, Python, SBML?

Metabolic and Protein Networks CellDesigner Cross-platform Works with SBW, Java, SBML