Bruno Maraviglia, Silvia Capuani, Girolamo Garreffa, Federico Giove, Tommaso Gili, Antonino M. Cassarà, Marco Carnì, Giovanni Giulietti, Marta Moraschi,

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Presentation transcript:

Bruno Maraviglia, Silvia Capuani, Girolamo Garreffa, Federico Giove, Tommaso Gili, Antonino M. Cassarà, Marco Carnì, Giovanni Giulietti, Marta Moraschi, Mauro Rebuzzi, Silvia De Santis MAGNETIC RESONANCE AND ITS APPLICATIONS TO THE STUDY OF BRAIN FUNCTION AND OTHER BIOLOGICAL TISSUES G1 Physics Dept, Sapienza University of Rome S. Lucia Foundation, Enrico Fermi Centre

G1 / Fermi Centre 2 RESEARCHHealthy HUMAN SCALE SMALL SCALE Pathological AD Spinal fMRIP300BNCTMaterialsLBDPD ncMRI Neuroenergetics MQ MRIMRI MethodsEpilepsyOSAS ModellingMethodsTheory fMRSExperimental EEG/fMRI Modelling Resting state

G1 / Fermi Centre 3 Neuroenergetics: experimental Journal Cereb Blood Flow Metab 27: (2007) Magn Reson Imaging 24: (2006)

G1 / Fermi Centre 4 Neuroenergetics: modelling Journal Cereb Blood Flow Metab, under revision

G1 / Fermi Centre 5 Greicius M et al PNAS 100: (2003) Fox MD et al PNAS 102: (2005) Damoiseaux JS et al 103: (2005) Resting state 0.01 Hz < f < 0.08 Hz Low frequency intrinsic correlations during rest the default network(s)

G1 / Fermi Centre 6 Resting state Cognitve modulation of the Default Mode Network Cereb Cortex, submitted t-score

G1 / Fermi Centre HMCIAD t Healthy controls vs AD & MCI patients R Resting state Neurology, submitted

G1 / Fermi Centre 8 Spinal cord fMRI Neuroimage, 42: (2008)

G1 / Fermi Centre 9 Neuroimage, 41: (2008) Neuronal current MRI Ultra Low Field NMR

G1 / Fermi Centre 10 Trabecular Bone Cartilage Boron Neutron Capture Therapy Advanced MRI of biological tissues Int J Radiat Oncol Biol Phys, (2008). J Magn Reson Imaging, submitted Biophys J, in preparation

G1 / Fermi Centre 11 PEOPLE:RESEARCH AGREEMENTS: MAIN COLLABORATIONS: CMRR, University of Minnesota, Minneapolis, USA Brigham & Women's Hospital, Boston, USA University of California, Berkeley, USA Dipartimento di Scienze Neurologiche, Università “Sapienza”, Roma, Italy Istituto Neurologico Mediterraneo, Isernia, Italy Dipartimento di Fisica, Università “Sapienza”, Roma, Italy (2 professors, 1 researcher, 3 research fellows, 2 PhD student, 1 technician) Fondazione Santa Lucia, Roma, Italy (1 researcher, 1 research fellow, MDs) RESOURCES

G1 / Fermi Centre 12 3T HEAD SYSTEM (HUMAN) Siemens Allegra Magnetic field: 3T Imaging Gradients: 40 mT/m Bore diameter: 63 cm RFPA: 4kW ( 1 H) System granted by: Fondazione Santa Lucia NMR Systems

G1 / Fermi Centre T VERTICAL BORE SYSTEM Bruker Avance 400 Magnetic field: 9.4T Diffusion gradients: 40 mT/m μ –Imaging gradients: 400mT/m High resolution Multinuclear Broad Band Observe Insert: 5 mm μ-Imaging probe Insert: 5 mm (1H) Insert: 8 mm (1H,13C,23Na) Insert: 8 mm (1H,13C) Site granted by: Dipartimento di Fisica, Università di Roma “Sapienza” NMR Systems

G1 / Fermi Centre 14 Bruker Biospec Magnetic field: 7T Imaging gradients: 25 mT/m μ –Imaging gradients: 40mT/m Bore diameter: 15 cm RFPA : 1kW System site granted by: Dipartimento di Fisica, Università di Roma “Sapienza” 7T HORIZONTAL BORE SYSTEM NMR Systems

G1 / Fermi Centre 15 EEG DEVICE EBNeuro Mizar 40 32/64 channels Sampling frequency: up to 16 kHz Dynamic range:  65.5 mV MRI compatibile NMR Systems

G1 / Fermi Centre 16 Neuronal current MRI Neuroimage 39: (2008)

G1 / Fermi Centre 17 Neuroimage, cited Neuronal current MRI

G1 / Fermi Centre 18