A short introduction.  Phylogenetic tree  A. nidulans specific  A. nidulans as a model organism  Reproduction cycles  A. nidulans vs. A. niger.

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Presentation transcript:

A short introduction

 Phylogenetic tree  A. nidulans specific  A. nidulans as a model organism  Reproduction cycles  A. nidulans vs. A. niger

 Largest Phylum of fungi (over ) species  Defining sexual feature: the ascus.

 Filamentous fungi  Fission rather then budding Binary Fission Budding

Cleistothecium plate of medium with A nidulans culture Order: Eurotiales The green and blue molds

 Aggresive colonization strategies  Adaptable to extreme environmental conditions ◦ For A. nidulans:  Temperature o C  pH  NaCl concentration<4.0 M

 Highly aerobic  Oligotrophy  Commercially the most important fungi Citric acid

 Creates a cleistothecium with ascus inside in the sexual cycle  Filamentous  Cells divide by fission  Green cultures  Can live under ‘extreme’ conditions  Highly aerobic  oligotroph

 Synonym: Aspergillus nidulellus  Teleomorph: Emericella nidulans  Anamorph: Aspergillus nidulans  Homothallic  Sexual, asexual and parasexual reproduction  Model organism

Why A. nidulans has been chosen as a model organism Small part of the phylogenetic tree

Sexual development in E. nidulans

Asexual development in A. nidulans

Parasexual cycle in A. nidulans

 Pulmonary infection  Cutaneous aspergillosis  Maxillary sinus disease  Guttural pouch mycosis (in horses)  Cerebral abscess  Endophtalmitis  Osteomyelitis  Superficial infections  Disseminated infections The atlas of clinical fungi p486

 Cell biology  Gene regulation  Mitosis  Intracellular functions of mitotic motors  Carbon & nitrogen regulation  Cell cycle  Fungal protein secretion  Gene regulation  Cell wall biosynthesis  Cell morphology  Carbon metabolism  Nutrient transport  Effects of environmental factors on enzyme production  Industrial use

 Sexual cycle  8 chromosomes  At least 9 cell types  Research focused on gene control  No sexual cycle  8 chromosomes  Research focused on protein production and excretion Descriptions.html