General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - https://commons.wikimedia.org/wiki/File:Smooth_muscle_tissue.jpg#/me.

Slides:

Advertisements

Similar presentations

Advertisements

Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Twitch time course Duration of twitch is largely governed by rate of sequestration.

Muscles and Muscle Tissue: Smooth Muscle Part C2 Prepared by Janice Meeking, W. Rose, and Jarvis Smith. Figures from Marieb & Hoehn 8 th ed. Portions copyright.

Ca Na H 2Na H Cyt ATP Sarcolemma I Ca Ca 3Na SR RyR 3Na Ca T-Tubule Na Ca NCX ATP 2K ATP PLB AP (E m ) [Ca] i Contraction 3Na 2K ATP by D.M. Bers.

SMOOTH MUSCLES Dr.Mohammed Sharique Ahmed Quadri Assistant Professor Department Basic Medical Sciences Division of Physiology Faculty of Medicine Almaarefa.

Fig Myofibrils are surrounded by calcium- containing sarcoplasmic reticulum.

Sliding Filament Theory How do muscles work…... Muscle Cell Structure n Muscles are broken into smaller muscle fibers n muscle fibers are broken into.

Muscles and Muscle Tissue

Chapter 12b Muscles.

WINDSOR UNIVERSITY SCHOOL OF MEDICINE

Muscular & Skeletal Systems. Figure 30.8_1 Muscle Several muscle fibers Single muscle fiber (cell)

ANNOUNCEMENTS Review Session this Friday: 12:20 Morrill 349 IMAGE523 Poster Team: Let’s Meet After Class Write Abstract Poster Design Discussion: Exam,

Myosin is a motor that runs along (or tugs at) actin. Actin-based movement of vesicles Chromosome migration Myosin-driven cell shape changes Muscle contraction.

Myofibrils are surrounded by calcium- containing sarcoplasmic reticulum.

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Neuromuscular Junction Figure 9.7 (a-c)

Contraction and Excitation of Smooth Muscle

7.2 Microscopic Anatomy and Contraction of Skeletal Muscle

MUSCLE CONTRACTION. Microscopic Anatomy of Skeletal Muscle Sarcomere Contractile unit of a muscle fiber Figure 6.3b.

Muscle Contraction.

Fiber Types Twitch durations vary from 10 to 200 msecs. This variation

Cardiac Muscle Involuntary –heart only Contracts & relaxes continuously throughout life –Contracts without nervous stimulation! –A piece of cardiac muscle.

Smooth Muscle  Spindle-shaped cells 2-10  m across & ~100  m long  Have a thin endomysium  Organized into longitudinal and circular layers  Found.

Smooth Muscle Unstriated muscle associated with visera. (Compare to skeletal muscle) Controlled by autonomic nervous system, hormones and paracrines. actin/myosin.

Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere.

Visceral Muscle. How is the gut organized anatomically?

Dr. Abdelrahman Mustafa

Non-striated Muscle I. Locations of non-striated muscle in vertebrate body GI tract (including internal, but not external sphincters) Blood vessels and.

X. Smooth Muscle Tissue.

U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Chapter 8: Contraction and Excitation of Smooth.

Muscular System. Facts about muscles… A skeleton cannot move by itself > 40% of the mass of the average human body is muscle Found everywhere in your.

____ Chapter 49 ~ Sensory and Motor Mechanisms ( Just focusing on motor mechanisms ) Motor Mechanisms.

Sliding Filament.

Muscular System Notes. Microscopic Muscle Anatomy  Myfibrils  About 1-2 micrometers in diameter  Length of a muscle fiber  Composed of multiple myofilaments.

Muscle Contraction Antagonistic Pairs -Two muscles work against each other to move body parts -One is contracting as the other relaxes -All animals have.

P.R. Smith, Cell Biology Skeletal Muscle Control.

Outline I. Types of Muscle II. Anatomy of Skeletal Muscle III. Sliding Filament Theory IV. Role of Ca+ in regulating muscle contraction.

Structure and Function of Skeletal Muscle

Contraction Mechanism Actin and myosin interact via to the sliding filament mechanism Resting State –Actin bound by caldesmon –Myosin light chain (MLC)

Lecture #21 Date ____ n Chapter 49 ~ Sensory and Motor Mechanisms.

Muscle Physiology Anatomy & Physiology/Tissues, Bones and Muscles.

Muscle contraction Public domain image. Muscle has two purposes Generate motion Generate force.

Comparison of Properties of: Skeletal, Smooth & Cardiac Muscle Comparison of functional organisation, electrical properties and mechanical properties of.

Muscle System. Root Words 3 Kinds of Muscle Skeletal Smooth (stomach, intestine) Cardiac.

An-Najah National University Faculty of Medicine Department of Physiology Anatomy and Physiology Instructor: Heba Salah Chapter 4: The Muscular.

MUSCLES LECTURE 14 CHAPTER 12 MECHANISMS OF CONTRACTION.

Muscle Types and Their Characteristics. Skeletal Muscle Anatomy.

U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Contraction and Excitation of Smooth Muscle.

General Shape of a Smooth Muscle Cell

Muscle Physiology ..

2. Striation Pattern of Sarcomere

A simplified diagram of smooth muscle contraction and the site of action of calcium channel-blocking drugs. Contraction is triggered (red arrows) by influx.

The Structure of Skeletal Muscle

Muscular system Part 3: Smooth Muscles.

Skeletal muscle sarcomere

EQ: How do our muscles in our body contract?

What does the following have in common?

Skeletal Muscle Microscopic Anatomy

Muscular system Part 3: Smooth Muscles.

Anatomy & Physiology Ms. Cohen

HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half

19 October 2009 This Week in Physiology:

Skeletal Muscle Microscopic Anatomy

Function of Muscles. Function of Muscles Characteristics of Muscles pg types: muscle cell = muscle fiber All muscles share some terminology Prefix.

Mark S Taylor, A.Marie McMahon, Jason D Gardner, Joseph N Benoit

Skeletal Muscle Anatomy

Ch. 12 Muscle Three types of muscle Skeletal muscle Anatomy

HISTOLOGY 1.12: MOLECULAR BASIS OF CROSS-STRIATION

Do now activity #1 What are the 3 types of muscle?

Presentation transcript:

General Shape of a Smooth Muscle Cell "Smooth muscle tissue" by Juan Carlos Fonseca Mata - Own work. Licensed under CC BY-SA 4.0 via Commons - dia/File:Smooth_muscle_tissue.jpg

Smooth Muscle Motor Units? "1029 Smooth Muscle Motor Units" by OpenStax College - Anatomy & Physiology, Connexions Web site. Jun 19, Licensed under CC BY 3.0 via Commons - ooth_Muscle_Motor_Units.jpg

Contraction Patterns in Smooth Muscles Phasic (quick, SkMus-like) and tonic contractions

EC Coupling in Smooth Muscle

Thin and Thick Filament Arrangements in Smooth Muscle

"1028 Smooth Muscle Contraction" by OpenStax College - Anatomy & Physiology, Connexions Web site. Jun 19, Licensed under CC BY 3.0 via Commons - oth_Muscle_Contraction.jpg "Actin myosin filaments" by Boumphreyfr - Own work. Licensed under CC BY-SA 3.0 via Commons - nts.png Contraction in Smooth Muscle -- Overview

Caldesmon

Caldesmon In Relaxed Fibers

Regulation of Smooth Muscle Contraction Thick Filament Regulation (on myosin light chain): -- Modulation by MLCK/MLCP -- Other Mechanisms Thin Filament Regulation (?): -- Does caldesmon have a regulatory role? -- Other mechanisms

Calcium and the Control of MLCK Leading to Control of the Myosin Light Chain

Contracted Smooth Muscle

There is Always a Reverse Process: MLCP phosphatase is inhibited by a Ca ++ dependent pathway (but in any case, its maximum activity is lower than MLCK)

SM Contraction and Relaxation: Ca ++ and the Regulation of Phosphorylation of the Myosin Light Chain

Regulation via the PKC Pathway

Latch Mechanism?