Cancer Susceptibilit y Genes Environment polycyclic aromatic Hydrocarbons PAH P450, glutathione S- transferase (GST) N- acetyltransferase (NAT) P. Perera Science :1068

Cancer prevention : a Life Course Approach Age Development of Cancer Fet al Life Adult Life Adolescenc e Infancy and Childhood Accumulat ed risk Genetic susceptibility to Cancer Older ages

Umbilical cord blood from newborns found an array of industrial chemicals, pesticides and pollutants. Ten newborns averaged 200 contaminants, and 209 pollutants had never before been detected in cord blood. Of the 287 chemicals found in newborn umbilical cord blood, 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause developmental problems. The dangers of exposure to these chemicals in combination has never been studied.

Of the 287 chemicals found in newborn umbilical cord blood, 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause developmental problems. The dangers of exposure to these chemicals in combination has never been studied. We detected 287 chemicals of 413 tested (69 percent) in umbilical cord blood samples from 10 newborn babies, with a range of between 154 and 231 for each child. We found 101 chemicals in all babies tested. organochlorine pesticides (DDT/ dieldrin) chemicals in a wide range of consumer products (perfluorochemicals, brominated fire retardants, PCBs), and chemicals from waste incineration and fossil fuel combustion (polyaromatic hydrocarbons, polychlorinated and polybrominated dioxins/furans, polychlorinated naphthalenes, mercury).

Synthetic halogenated chemicals increase liver tumors after early life-stage exposure. TCDD a prototypical endocrine-disrupting compound, 2,3,7,8-tetra chloro dibenzo-p-dioxin, has been shown to be a developmental toxicant of the mammary gland in rodents. Dioxin alters multiple endocrine systems, and its effects on the developing breast involve delayed proliferation/differentiation of the mammary gland, as well as an elongation of the window of sensitivity to potential carcinogens. Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection. Endocrine disruptors during breast development Birnbaum SL Environ Health Perspect 111:389–394 (2003).

Endocrine disruptors during breast development Birnbaum SL Environ Health Perspect 111:389–394 (2003). Mammary gland tissue from LE rats exposed in late gestation to ATR is atrazine ( a pesticide) and TCDD or 2,3,7,8-tetrachlorodibenzo-p dioxin. ATR 100mg/kg TCDD 1  g/kg PND 4 PND 33 PND 68 Control atrazinedioxin

Mortalidad por tumores malignos de mama* Chile Tasas por *femenino Fuente: DEIS/MINSAL

Mortalidad por tumores malignos de próstata Chile Tasas por Fuente: DEIS/MINSAL