Large glands of digestive system Pancreas Function of liver : 1. Syntesis: Bile Plasma proteine Plasma lypoproteines (vitamine K, D, E, A, cholesterine)

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Presentation transcript:

Large glands of digestive system Pancreas

Function of liver : 1. Syntesis: Bile Plasma proteine Plasma lypoproteines (vitamine K, D, E, A, cholesterine) 2. Detoxication 3. Destruction of spent red cell and reclamation of their constituens 4. Universal haemopoetic organ 5. Endocrine - somatomedine

LIVER & Pancreas LIVER Bile Hepatic artery Portal vein GI worm Hepatic veins

Liver vasculature

Liver lobule

Liver specimen

Liver specimens

HEPATIC PARENCHYMA epithelial working tissue Plate of hepatocytes SINUSOID Plate of hepatocytes Endothelial cells Space Disse SINUSOID Kupffer cell blood PIT cell Itto cell (stellate cell)

CELL TYPES & ARRANGEMENT OF LIVER Microvilli Hepatocytes in plates Bile canaliculus SPACE OF DISSE Fenestrated Endothelial cells SINUSOIDKupffer cell STELLATE CELL HEPATOCYTE ENDOTHELIAL CELL KUPFFER CELL STELLLATE CELL

Hepatocyte, blood capilaries, bile canaliculus

Hepatocyte electron microhpoto

bile canaliculus electron microhpoto

Hepatocyte, blood capilaries, bile canaliculus

Schema of clasiccal and portal lobules and liver acinus

gallbladder

Epithelium of gallbladder

pancreas

Acinus and duct of pancreas

Homogenic and zymogenic zones

pancreatocyte

Langerhans islets

Classification of insulocytes: Cells%hormonfuncion В70-75 insulin insulin Lowers blood glucose, activates the formation of glycogen in the cells А20-25glucagon Increases blood glucose by glycogen clutch D5-10 VIP (vasoactive intestinal pep- tide), gastrin Reduces BP and simulates juice and hormone secretion D1-D1-D1-D1-1-2somatostatin Delays secretion of insulin and glucagon РР, F 2-5 pancreatic polypeptide Inhibits secretion of pacreatic juice

В and А cells inside Langerhan’s Islands

Insulocytes and fenestrated blood capillaries

Salivary glands Parotide, Submundibular, Sublingual+ numerous minor FUNCTIONS І. Exocrine 1. Food moistening 2. Desinfection 3. Digestion 4. Articulation ІІ. Endocrine (parotin, insulin-like factor, epithelium growth factor, nerve growth factor, vaso-active intestinal polypeptide, glucagon, callicrein, renin...) ІІІ. Excretion ІV. Homeostatic Saliva 1.Water-99% 2.Mineral (Na, K, Cа, Fe …) 3. Organic (enzymes, mucous) Cells (leukocytes, epitheliocytes)

MFU– ACINUS secretory potion+ intrecallated duct+ striated duct

Parotid gland

Submandibular gland

submandibular

Sublingual gland