Large glands of digestive system Pancreas
Function of liver : 1. Syntesis: Bile Plasma proteine Plasma lypoproteines (vitamine K, D, E, A, cholesterine) 2. Detoxication 3. Destruction of spent red cell and reclamation of their constituens 4. Universal haemopoetic organ 5. Endocrine - somatomedine
LIVER & Pancreas LIVER Bile Hepatic artery Portal vein GI worm Hepatic veins
Liver vasculature
Liver lobule
Liver specimen
Liver specimens
HEPATIC PARENCHYMA epithelial working tissue Plate of hepatocytes SINUSOID Plate of hepatocytes Endothelial cells Space Disse SINUSOID Kupffer cell blood PIT cell Itto cell (stellate cell)
CELL TYPES & ARRANGEMENT OF LIVER Microvilli Hepatocytes in plates Bile canaliculus SPACE OF DISSE Fenestrated Endothelial cells SINUSOIDKupffer cell STELLATE CELL HEPATOCYTE ENDOTHELIAL CELL KUPFFER CELL STELLLATE CELL
Hepatocyte, blood capilaries, bile canaliculus
Hepatocyte electron microhpoto
bile canaliculus electron microhpoto
Hepatocyte, blood capilaries, bile canaliculus
Schema of clasiccal and portal lobules and liver acinus
gallbladder
Epithelium of gallbladder
pancreas
Acinus and duct of pancreas
Homogenic and zymogenic zones
pancreatocyte
Langerhans islets
Classification of insulocytes: Cells%hormonfuncion В70-75 insulin insulin Lowers blood glucose, activates the formation of glycogen in the cells А20-25glucagon Increases blood glucose by glycogen clutch D5-10 VIP (vasoactive intestinal pep- tide), gastrin Reduces BP and simulates juice and hormone secretion D1-D1-D1-D1-1-2somatostatin Delays secretion of insulin and glucagon РР, F 2-5 pancreatic polypeptide Inhibits secretion of pacreatic juice
В and А cells inside Langerhan’s Islands
Insulocytes and fenestrated blood capillaries
Salivary glands Parotide, Submundibular, Sublingual+ numerous minor FUNCTIONS І. Exocrine 1. Food moistening 2. Desinfection 3. Digestion 4. Articulation ІІ. Endocrine (parotin, insulin-like factor, epithelium growth factor, nerve growth factor, vaso-active intestinal polypeptide, glucagon, callicrein, renin...) ІІІ. Excretion ІV. Homeostatic Saliva 1.Water-99% 2.Mineral (Na, K, Cа, Fe …) 3. Organic (enzymes, mucous) Cells (leukocytes, epitheliocytes)
MFU– ACINUS secretory potion+ intrecallated duct+ striated duct
Parotid gland
Submandibular gland
submandibular
Sublingual gland