Tumor markers. ویژگی تومور مارکرها اختصاصی باشند توانایی تشخیص زود رس تومور را داشته باشد.

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Tumor markers

ویژگی تومور مارکرها اختصاصی باشند توانایی تشخیص زود رس تومور را داشته باشد

تاریخچه بنس جونز 1847 AFP 1963 CEA 1965

آنزیم ها اولین تومور مارکرها اغلب فاقد ویژگی و حساسیت

ALP کبد متاستاز استخوان ایزوآنزیم جفتی در سرطان تخمدان، نای، دستگاه گوارش

LDH غیر اختصاصی سنجش ایزوآنزیم ها بیشتر بیانگر درگیری بافتها است

NSE

PAP

PSA

total PSA = Complex PSA + free PSA Complex PSA= PSA-A 1 CT & PSA-A 2 MG Total PSA assay often fPSA+ PSA-ACT

PSA non prostatic NAFPSA High risk for Breast cancer= lower NAFPSA

Level of PSA and fPSA in BPH & PCa

Sensitivity & specificity of PSA and fPSA

آنتی ژن های جنینی

AFP

CEA

مارکرهای کربوهیدراتی

CA 15-3

CA 19-9

CA 125

CA 19-9

CA 242

CA Metastatic breast cancer

CA 549 Active brest cancer

CA 72-4 کارسینومای مجاری معدی - روده ای و تخمدان

CA 72-4

Hormones

سیتوکراتین ها

CYFRA 21-1

Lung cancer

SCC

Other tumor markers

HE4

Malignant mesothelioma

MESOMARK

ProGRP

S100

Sample collection

International standard

Detection limit

Hook effect

Interference