Online additional material Appendix Table 1: Medications Groups Appendix Table 2: Doctors' orders in hemodialysis units Additional Figure 1: Beta Blockers Additional Figure 2: Statins Additional Figure 3: Anti-arrhythmics Additional Figure 4: Nitrates Additional Figure 5: Doxazosin Additional Figure 6: Furosemide Additional Figure 7: Oral hypoglycemics Additional Figure 8: Antidepressants Additional Figure 9: Calcium Carbonate Additional Figure 10: Vitamin D analogs Additional Figure 11: Aspirin Additional Figure 12: Calcium Chanel Blockers Color coding for Additional Figures

Appendix table 1: Medications Groups. Number of patients who use the medication (No) Percent of patients wo use this drug (%) Antidepressants Mirtazapine, paroxetine, escitalopram, amitryptiline, fluvoxamine, escitalopram Doxazosin Anti-arrhythmics Amiodarone, flecainide, propafenone Oral hypoglycemics Glibencamide, repaglinide, acrabose, metformin Nitrates Glyceryl trinitrate,Isosorbide mononitrate,Isosorbide dinitrate ACE inhibitors and ARB's* Captopril, ramipril, enalapril, losartan, cilazapril, valsartan Furosemide Calcium Chanel Blockers Felodipine,amlodipine,nifedipine,verapamil,lercandipine Beta Blockers Metoprolol, Atenolol, Carvedilol, Bisoprolol Statins Simvastatin, Pravastatin, Atorvastatin Aspirin Calcium Carbonate Alfacalcidol *Includes 4 cases of combined ARB's and Hydrochlorothiazide in one pill

Appendix Table 2: Doctors' orders in HD units All medications not including Calcium Carbonate and Alfacalcidol Calcium Carbonate AlfacalcidolAll Medications Start treatment Increase dose Reduce dose Stop the treatment Switch to different drug of the same family23 Total

Figure 1 Plate A : Patients' Purchase Figure 5 Plate C : Adherence Figure 1 Plate B : Documentation By Nurses Figure 5 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 1: Beta Blockers - Medication purchase, reporting and adherence patterns

Figure 2 Plate A : Patients' Purchase Figure 2 Plate C : Adherence Figure 2 Plate B : Documentation By Nurses Figure 2 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 2: Statins – Medication purchase, reporting and adherence patterns

Figure 3 Plate A : Patients' Purchase Figure 3 Plate C : Adherence Figure 3 Plate B : Documentation By Nurses Figure 3 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 3: Anti-arrhythmics – Medication purchase, reporting and adherence patterns

Figure 4 Plate A : Patients' Purchase Figure 4 Plate C : Adherence Figure 4 Plate B : Documentation By Nurses Figure 4 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 4: Nitrates- Medication purchase, reporting and adherence patterns

Figure 5 Plate A : Patients' Purchase Figure 5 Plate C : Adherence Figure 5 Plate B : Documentation By Nurses Figure 5 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 5: Doxazosin- Medication purchase, reporting and adherence patterns

Figure 6 Plate A : Patients' Purchase Figure 6 Plate C : Adherence Figure 6 Plate B : Documentation By Nurses Figure 6 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 6: Furosemide- Medication purchase, reporting and adherence patterns

Figure 7 Plate A : Patients' Purchase Figure 7 Plate C : Adherence Figure 7 Plate B : Documentation By Nurses Figure 7 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 7: Oral hypoglycemics – Medication purchase, reporting and adherence patterns

Figure 8 Plate A : Patients' Purchase Figure 8 Plate C : Adherence Figure 8 Plate B : Documentation By Nurses Figure 8 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 8: Antidepressants – Medication purchase, reporting and adherence patterns

Figure 9 Plate A : Patients' Purchase Figure 9 Plate C : Adherence Figure 9 Plate B : Documentation By Nurses Figure 9 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 9: Calcium Carbonate Medication purchase, reporting and adherence patterns

Figure 10 Plate A : Patients' Purchase Figure 10 Plate C : Adherence Figure 10 Plate B : Documentation By Nurses Figure 10 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 10: Vitamin D analogs- Medication purchase, reporting and adherence patterns

Figure 11 Plate A : Patients' Purchase Figure 11 Plate C : Adherence Figure 11 Plate B : Documentation By Nurses Figure 11 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 11: Aspirin – Medication purchase, reporting and adherence patterns

Figure 12 Plate A : Patients' Purchase Figure 12 Plate C : Adherence Figure 12 Plate B : Documentation By Nurses Figure 12 Plate D : Relationship Between Nurses' documentation and patient purchase Additional Figure 12: Calcium Chanel Blockers- Medication purchase, reporting and adherence patterns