Synaptic Transmission. Electrical & Chemical Synapses Electrical & Chemical Synapses.

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Presentation transcript:

Synaptic Transmission

Electrical & Chemical Synapses Electrical & Chemical Synapses

Events Involved in Transmission at a Chemical Synapse

Local Recycling of Synaptic Vesicles in Presynaptic Terminals

Presynaptic Proteins Implicated in Neurotransmitter Release

Molecular Mechanisms of Neurotransmitter Release

Diseases that Affect the Presynaptic Terminal Lambert-Eaton myasthenic syndrome = Ab mediated Several congenital forms result in fewer or smaller vesicles = less transmitter

Toxins That Affect Transmitter Release Toxins cleave SNAREs Tetanus affects inhibitory interneurons = hyperexcitation of muscles Botulism paralyzes peripheral muscles = do not contract

Toxins That Affect Transmitter Release Black widow venom = exocytosis w/o calcium Binds to CL1 and neurexin, neurexin binds to synaptotagmin

Diseases Caused by Altered Ion Channels FHM = familial hemiplegic migraine EA2 = episodic ataxia CSNB = congenital stationary night blindness

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