Multi-dimensional Dynamic Visualization of Clinical Data Jianmei Wang Roche Products Limited October

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Background Software tool: Not open source. Uses Adobe Flash. Online tool Google Motion Chart offers limited functionality “Joy of Stats” by Hans Rosling

Opportunity Roche Data Visualization Tool: A new software tool to create animated graphics to visualize time series data from clinical trial Now Future Long tables of summary data over time Long listings of individual patient data over time Line plots or 1 variable at a time Large dataset embedded in animated graphics Many questions can be answered in the visualization without a new outputs

Example 1. Neutrophil depression in a paediatric study Background: Drug cause depression of neutrophil count, potentially increasing risk of infections. A better understanding of the abnormal labs is needed. Table 1 Patients with a Depression in Neutrophils to CTC Grade 3 or Worse Current output:

Example 1. Demo of Animated Graphics Study day

Example 2. Different aspect of treatment response in two clinical studies Active Current outputs: One component at a time

Example 2. Demo of Animated Graphics

Demo of Graphics Tool

More Information: me

Recommendation from the tool designers Explain it well the first time Treat the animated graphic analysis as exploratory analysis Follow data sharing guideline, as the underlying data is embedded in the.svg output files Use animation only when it adds value

Potential use Data monitoring for safety and data quality? Communication? Exploratory analysis? Quick review of large datasets?

Thanks! Internal collaborator: Jeff Tomlinson, Olivier Harari Sponsor: Roche global medical affairs Developer: BrainyPro Inc.

Doing now what patients need next