HIV infection(AIDS) Dr. Yingguo Ding Dept. of Dermatology First Affiliated Hospital Sexually transmitted disease - Cutaneous manifestations and management

Pathogenesis Human immunodeficiency virus (HIV) I type &II type – isolated from blood, serum, genital secretions, breast milk, cerebrospinal fluid, urine, saliva and lacrimal fluid. Main infection routes – Sexual activity – Blood infection(blood products transfusion, sharing of needles for drugs, needle stick accidents) – Mother-to-child infection

Mechanism

Infection Tumor Non-infectious severe,atypical,bigotry Cutaneous manifestations of AIDS - three categories

Infection ： 1. Oral hairy leukoplakia (OHL) ：  20 ％ Early specific sign EBV correlating Candida (+)

2.Viruse infections ： - Herpes zoster/Herpes simplex - CA ： giant - Warts - CMV

3.Fungi infections ： - Tinea - Candidiasis - Cryptococcosis 2 ％  9 ％， multiformic ，

Cryptococcosis

4.Bacteria infections: - folliculitis,impetigo … - TB ： warty tuberculosis

Tumor: 1.Kaposi ’ s sarcoma  30 ％ risk generalized progressive painful systemic

2. non-Hodgkin's lymphoma( NHL): 4 ％～ 10 ％ 3.Other ： Mycosis Fungoides(MF) 、 squamous cell carcinoma(SCC) 、 basal cell carcinoma(BCC) 、 malignant melanoma(MM) …

1.Seborrheic dermatitis ： 70 ％～ 80 ％, early stage 2.Psoriasis: ～ 5 ％， first sign, mark of poor prognosis 3.hair abnormalities: alopecia,white hair,prolonged eyelashes … 4.Drug eruptions Non-infectious

Ichthyosiform lesions

There is no cure or vaccine for HIV yet. Important ： epidemic prevention