Joint Power 24 Presented by Peter Jo, Rph President Super Value Nutraceuticals, Corp.

 The number-one disability in US  Joint disorders aren’t fatal - only minimal scientific research compared to heart disease, cancer, and AIDS. Because of the lack of real concern, Physicians who have to treat their arthritis patients with less-than-ideal methods.

 There is an enormous information about the role of nutrients play in healing joints. But somehow, this information has not much been utilized in America.  In several European countries - some nutrients now are the drugs of choice for the treatment of osteoarthritis.  e

 70 million adults reported by CDC (43 million diagnosed by doctors)  CDC estimates adding 22 million by 2030

 The story of “Vitamin I” (myth of Ibuprofen)  Risk all sorts of complications (high BP, heart attacks, strokes, GI bleeding, etc)  Some drugs may even make arthritis worse.

 Overnight heroes turns out the devils which destroy the whole body. (long term use)  Side effects: from Bone deterioration to Weight gain

 Next roller-coaster riding after corticosteroids (100 years up and down since Aspirin)  Indomethacin, Sulindac, Piroxicam, Naproxen relay

 The British medical Journal in 2004 : A Shocking Discovery “NSAIDs can reduce short-term in osteoarthritis of the knee slightly better than placebo, but the current analysis does not support prolonged use of NSAIDs for this condition. As serious adverse effects are associated with oral NSAIDs, only limited use can be recommended.”

 1984 Rx-to-OTC switch started and OTC NSAIDs on the market.  People are gobbling down OTC NSAIDs almost like candy. (ex. Vitamin I)

 2005 Journal of Rheumatology “OTC analgesic including NSAIDs are widely used, are frequently taken inappropriately and potentially dangerously, and users are generally unaware of the potential for adverse side effects.”

 1999 Initial excitement of selective COX-2 inhibitors- Vioxx, Bextra, Celebrex  The danger of COX-2 inhibitors: an increased risk of blood clots.

 Until the fall of 2004: one of the darkest hours in the history of American medicine : More than 100,000 people suffered heart attack s and strokes. According to FDA safety officer David Graham, MD, as many as 40,000 people may have died.  First Vioxx and then Bextra were pulled off the market.

 To understand diseases of the joint, we need to look at normal healthy joint.  Joints are held together by joint capsule that is designed to allow smooth movement between adjacent bones.

 The bone ends are covered by the cartilage over which the joint moves.  A synovial membrane which encloses the joint space secretes synovial fluid.

 Arthritis: Inflammation of the joint: joint tissue response to mechanical, chemical, and immunological challenge.  Inflammation: Arachidonic acid products: prostaglandin(PGE-2) by cyclooxygenase(COX-2) and leukotriene(LTB4) by lipoxygenase(5- LOX)

Dietary Factors COX 2 5-Lipooxygenase Prostaglandin E2Leukotreine B4 Phospholipase A2 Arachidonic Acid Willow Bark Feverfew Bromelain Boswellia

1.Bromelain: reduce swelling, bruising, healing time, and pain following surgery and physical injuries. 2.Boswellia:works by blocking 5-LOX, which is the first enzyme released in the metabolic pathway leading to the synthesis of the immune system cytokines known as leukotrienes.

3.Feverfew: The most common, scientifically documented benefit of feverfew extract is in the prophylactic treatment of migraine headaches. Folk remedies for arthritis and rheumatic pain 4.Willow bark: used to ease pain and reduce inflammation. Researchers believe that salicin, found in willow barkis responsible for these effects.

5.Glucosamine: which is produced naturally in the body, plays a key role in building cartilage, the tough connective tissue that cushions the joints. 6.Chondroitin: A major component of cartilage which helps to keep cartilage healthy by absorbing fluid into the connective tissue and provides the building blocks to produce new cartilage.

7.MSM:form connective tissue and slow the nerve impulses that transmit pain signals. 8.Hyluronic acid: improve the mobility of osteoarthritis patients by alternations in the synovial fluid viscoelasticity, cartilage metabolism, and inflammation.