Recent advances in the monitoring and management of diabetic ketoacidosis by T.M. Wallace, and D.R. Matthews QJM Volume 97(12):773-780 November 29, 2004.

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Presentation transcript:

Recent advances in the monitoring and management of diabetic ketoacidosis by T.M. Wallace, and D.R. Matthews QJM Volume 97(12): November 29, 2004 QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

(a) Increased lipolysis results in the production of acetylCoA from fatty acids which acts as the substrate for hepatic synthesis of ketone bodies (acetoacetate, beta-hydroxybutyrate and acetone). T.M. Wallace, and D.R. Matthews QJM 2004;97: QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

Glucose and β-OHB profiles in two patients admitted with DKA. There is an initial reduction in β- OHB and glucose with treatment. T.M. Wallace, and D.R. Matthews QJM 2004;97: QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

The time course for blood glucose (squares), β-hydroxybutyrate (β-OHB, diamonds) and bicarbonate (triangles) in hours from initiation of treatment. T.M. Wallace, and D.R. Matthews QJM 2004;97: QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

Guidelines for the use of the ketone meter in out-patients. T.M. Wallace, and D.R. Matthews QJM 2004;97: QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.