Principles of Oncology Professor Ravi Kant
Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow Omnes cellula e cellula Theodor Boveri-1914 chromosomal abnormalities Watson & Crick DNA
Apoptosis
Cancer cells → Undemocratic Autonomous Avoid Apoptosis Neoangiogenesis Invasion Proliferation
Cancer cellls Genomic instability
Malignant transformation
Gompertzian curve
Kaplan-Meier Kaplan-Meier Curve
Clinical implication of Gompertzian curve
Genetic Cancer Breast Thyroid
Prevention of Cancer Diet Life style
Early detection of cancer Screening- for cancer of Oral: Intraoral examination Breast: Mammography Stomach: Upper GI endoscopy Prostate: PSA level in serum
Diagnosis & Staging
Rx of Cancer Surgery Radiotherapy Chemotherapy Isotope Therapy Immunotherapy Immuno-modulation Receptor blockade of cancer
Team Multidisciplinary approach
Rx of T= Tumour N= Node M= Metastasis
Palliation
End of life care ? Nobel prize
Quality of life Dignity
Thanks