Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

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Presentation transcript:

Principles of Oncology Professor Ravi Kant

Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow Omnes cellula e cellula Theodor Boveri-1914 chromosomal abnormalities Watson & Crick DNA

Apoptosis

Cancer cells → Undemocratic Autonomous Avoid Apoptosis Neoangiogenesis Invasion Proliferation

Cancer cellls Genomic instability

Malignant transformation

Gompertzian curve

Kaplan-Meier Kaplan-Meier Curve

Clinical implication of Gompertzian curve

Genetic Cancer Breast Thyroid

Prevention of Cancer Diet Life style

Early detection of cancer Screening- for cancer of Oral: Intraoral examination Breast: Mammography Stomach: Upper GI endoscopy Prostate: PSA level in serum

Diagnosis & Staging

Rx of Cancer Surgery Radiotherapy Chemotherapy Isotope Therapy Immunotherapy Immuno-modulation Receptor blockade of cancer

Team Multidisciplinary approach

Rx of T= Tumour N= Node M= Metastasis

Palliation

End of life care ? Nobel prize

Quality of life Dignity

Thanks