Summary of “Fecal Worm Egg Count Reduction” Trials in Merck Animal Health National Data Base Donald H. Bliss1 Robert D. Moore2 William G. Kvasnicka3 1MidAmerica Ag Research, Verona, WI 2College of Agriculture, Biotechnology & Natural Resources, University of Nevada 3University of Nevada, Professor Emeritus

Protocol for Fecal Worm Egg Count Reduction Test (FECRT) All clinics agreed to use a standard protocol: 20 samples taken at the time of treatment. 20 samples taken 14-days after treatment. Pre-/post-treatment samples sent to same lab: ● Treatment not revealed until test completed. ● Modified WI Sugar Flotation Technique (Eggs/3 g). ● Results sent to participating clinic and entered in Merck Animal Health National Database.

Fecal Egg Count Reduction Test Results 250+ Participating Vet Clinics. 24+ States Represented. 580+ Trials Completed. 19,996 Samples Analyzed. 10,069 Pre-treatment Samples. 9,927 Post-treatment Samples.

Table 1: Efficacy Summary for Fecal Egg Count Reduction Test Conducted with Macocyclic Lactone Endecticide Pour-On Products (2009-2013). _________________________________________________________________ No. of No. of Egg Counts/3g* Percent Products Trials Samples Pre-Rx Post-Rx Efficacy(%) Pour-ons: Ivomec® PO 3 108 59.1 43.2 27.0% Ivermectin PO 26 1,164 71.5 38.7 45.8% Dectomax® PO 10 431 46.8 16.4 65.1% Cydectin® PO 11 477 58.3 16.0 72.5% Eprinex® PO 3 144 49.3 38.0 22.9% --------------------------------------------------------------------------------- PO Summary 53 2,324 62.1 30.0 51.6% _________________________________________________________________ *All samples taken at Rx and again 14-days post-Rx. **Updated Jan. 3, 2013

No. of No. of Egg Counts/3g* Percent Table 2: Efficacy Summary for Fecal Egg Count Reduction Test Conducted with Injectable Macrocylic Lactone Endecticide Products (2009-2013). __________________________________________________________________________________ No. of No. of Egg Counts/3g* Percent Products Trials Samples Pre-Rx Post-Rx Efficacy Injections: Ivomec® Inj. 15 984 66.5 36.8 44.6% Ivomec® Plus 10 413 97.4 51.7 46.9% Dectomax® Inj. 23 966 63.1 16.0 74.6% Cydectin Inj. 7 311 35.0 6.0 82.8% Ivermectin Inj. 10 506 90.7 55.0 39.4% Generic Ivo Plus 4 149 92.9 46.7 49.8% ------------------------------------------------------------------------------------------ Inj. Summary: 69 3,329 71.7 32.1 55.2% _____________________________________________________________ *All samples taken at Rx and again 14-days post-Rx. **Updated Jan. 3, 2013  

Table 3: Efficacy Summary for Fecal Egg Count Reduction Test Conducted with Various Safe-Guard® & Panacur® Formulations. ______________________________________________________________________________________ No of No of Egg Counts/3g* Percent Products Trials Samples Pre-Rx Post-Rx Efficacy Panacur® Drench 32 1,296 59.3 0.7 98.8% SG Drench/Paste 71 2,979 65.0 0.8 98.7% Summary-Drench 103 4,275 63.2 0.8 98.7% ------------------------------------------------------------------------------------ SG Feed/1.96% 28 1,449 45.6 0.2 99.5% SG Mineral 7 265 36.4 1.6 95.5% Liquid Feed 10 388 42.3 1.4 96.6% Cubes/blocks/Paste 10 447 33.7 2.0 94.0% ------------------------------------------------------------------------------------ Overall Summary** 158 6,824 55.7 0.8 98.5% ________________________________________________________________ * All samples taken at Rx and again 14-days post-Rx – Updated Jan. 3, 2013. ** Note: Coccidia prevalence was reduced by 56.5%.

Table 4: Efficacy Summary for Fecal Egg Count Reduction Test Conducted with Safe-Guard®/ Panacur® in Combination with Various Endecticide Formulations. _____________________________________________________________________________________ Combination No of No of Egg Counts/3g Percent Product Trials Samples Pre-Rx Post-Rx Efficacy -------------------------------------------------------------------------------------------------------Safe-Guard® or Panacur ® plus: Ivomec® Inj./plus/PO 19 917 77.2 0.4 99.4% Ivermectin PO/Inj. 28 1,155 76.7 0.4 99.4% Dectomax® Inj./PO 6 223 83.4 0.1 99.8% Cydectin PO 1 41 134.0 0.1 99.9% ---------------------------------------------------------------------- Combination 54 2,366 78.7 0.4 99.4% Summary _______________________________________________________ Note: Coccidia prevalence was reduced by 76.9% *Updated Jan. 3, 2013

Table 5: Efficacy Summary for Fecal Egg Count Reduction Test Conducted for all Products. ______________________________________________________________________________________ Number of Number of Egg Counts/3g** Percent Products Trials Samples Pre-Rx Post-Rx Efficacy(%) Endecticide Injectable: 69 3,329 71.7 32.1 55.2% Pour-On: 53 2,324 62.1 30.0 51.6% Safe-Guard® /Panacur® 158 6,824 55.7 0.8 98.5% Combination Treatment*** 54 2,336 78.7 0.4 99.4% ______________________________________________________________________ *Updated Jan. 3, 2013, **All samples taken at Rx and 14-days post-Rx. *** Safe-Guard® plus an Endecticide.

Table 6: Comparison of FECRT Efficacy for ML Pour-Ons 2008(AABP) vs Table 6: Comparison of FECRT Efficacy for ML Pour-Ons 2008(AABP) vs. 2013(Jan. 3) Products No. of Trials Percent No. of Trials Percent Efficacy 2008 Efficacy 2009-2013 Efficacy Change --------------------------------------------------------------------------------------------------------- Ivomec® 8 72.3% 3 27.0% - 45.3% Ivermectin 35 59.7% 26 45.8% - 23.9% Dectomax® 8 78.9% 10 65.1% - 13.8% Cydectin® 9 67.2% 11 72.5% + 5.3% ---------------------------------------------------------------------------- Summary 60 66.1% 53 51.2% - 14.9% Updated Jan. 3, 2013

Table 7: Comparison of FECRT Efficacy ML Injectables: 2008(AABP) vs Table 7: Comparison of FECRT Efficacy ML Injectables: 2008(AABP) vs. 2013(Jan. 3) Products No. of Trials Percent No. of Trials Percent Efficacy 2008 Efficacy 2009-2013 Efficacy Change ----------------------------------------------------------------------------------------------- Ivomec® Inj. 6 76.2% 15 44.6% - 31.6% Ivomec® Plus 6 42.6% 10 46.9% + 4.3% Ivermectin or Ivermectin plus 1 50.0% 14 41.4% - 8.6% Dectomax® 11 90.5% 23 74.6% - 15.9% Cydectin® 2 98.1% 7 82.8% -15.3% ---------------------------------------------------------------------------- Summary 26 72.5% 69 55.2% -17.3% Updated January 3, 2013