Development of Harvard Catalyst Imaging Consultation Service C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD February 27,2009

Agenda 1 Harvard Catalyst Imaging Consortium Technology and Expertise IT Structure Why be a consultant ? Educational Opportunities Contact

Harvard Catalyst: The History and the Basics 2 GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued –BWH/MGH imaging cores (CT/AVD/GS) CTSA 2007(Roadmap initiative- EAZ ) HU- Response-Harvard Catalyst –(PI Lee Nadler/Co-Director: Steve Freedman) We are a pan-Harvard enterprise dedicated to improving human health by: –Creating Connections –Enabling research At the Cutting Edge of discovery –Nurturing clinical and translational researchers

National Effort in C/T Research 38 AHC/23 states 3 Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 Source: Duke Mayo Clinic Cornell J.Hopkins UC Davis Wash. U. Northwestern Emory U. Imaging programs-(Dan Sullivan/RSNA)

Institutions participating in Harvard CTSC 4 Academic Healthcare Centers Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Specialty Hospitals and Institutes Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare Red –Imaging Consortium Year 01 total budget: $22,148,106

Harvard catalyst Programs (Selected list) –Biomedical Informatics-Kohane –Community engagement –Design and Biostats –Dev of Novel CT methodologies-Vikas –Diversity/Health Disparities research –Ethics –Linkages-HL, HBS, Kennedy School etc –Pilot studies –Regulatory-BB –Research Education 5

Harvard catalyst Programs –Translational Technologies and Resources- GW Imaging –increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 6

Pilot funds Eligibility: Any individual with a Harvard faculty appointment regardless of degree. Funds: Pilot grants ranging from $40,000 to $100,000 for one year. Majority of the awards will be in the $50,000 to $75,000 range. Application for second year of funding will be considered if benchmarks are achieved. Occasionally grants up to $200,000 will be awarded. Deadlines: RFA Posted for Round One - September 4, 2008 Preliminary Proposal (two page) Due - October 15, 2008 Semi-Finalists Selected - November 7, 2008 Secondary Application (5 pages) Due - December 7, 2008 Round One Pilots Grants Funded - January 15, 2009 Contact: Harvard Catalyst Research Navigators

Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Imaging Consortium Team 8

Mission of the Imaging Consortium 9 Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment.

Harvard Catalyst website 10 Access to resources and profiles

Image Consortium Consultation Service 11 Access to the consultation service:

Technologies and Expertise 12 Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

XNAT-PACS-i2b2 Integration 13 IT Catalyst infrastructure: –i2b2: scalable computational framework to help translation of genomic findings. –BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. –NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer.

XNAT Enterprise Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers XNAT-PACS-i2b2 Integration 14 Slicer: Data visualization analysis

Becoming an Imaging Consultant 15 Potential benefits of being an active collaborator: –Good framework for research –Research opportunities through collaborations –Meeting experts out of radiology –Networking with imaging cores outside of Boston Example: standardization of physiologic monitoring system for fMRI

Educational Opportunities proposal 16 Nanocourse: Imaging 101 More advanced classes: –Tumor metrics –Radiation safety issues for IRB submission –Hands-on classes on data analysis –Imaging perfusion –Example:

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