Active and passive immunization. Passive immunization Substitution of missing specific antibodies protecting against infectious disease or treating the.

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Presentation transcript:

Active and passive immunization

Passive immunization Substitution of missing specific antibodies protecting against infectious disease or treating the infectious disease. Used mainly in infectious diseases or diseases caused by toxins. Prompt but short-term effect. No immunological memory is induced.

Active immunization Induction of immune memory by harmless antigen. In the case of infection by a pathogen prompt secondary immune response protects the immunized person from the disease. Has protective, but no therapeutic effect.

Active and passive immunisation

Antisera used in human medicine Against bacterial infections: Tetanus (human), Diphteria (equine), Botulism (equine) Against viral infetions: Hepatitis B (human), Rabies (equine), Varicella-zoster (human), CMV (human), tick-born encephalitis (human), hepatitis A, measles and other viral infections (pooled human immunoglobulin) Against snake or black widow spider toxins Anti Rh

Edward Jenner Discovery of small pox vaccine

Primary and secondary immune response gsbs.utmb.edu/microbook/ch001c.htm

Downloaded from: StudentConsult (on 18 July :29 AM) © 2005 Elsevier Formation of memory cells after antigenic challenge

Downloaded from: StudentConsult (on 18 July :29 AM) © 2005 Elsevier Primary and secondary immune response

„Classical“ vaccines Atenuated microbes: BCG (against TBC), mumps, measles rubella, varicella, cholera, yellow fever, poliomyelitis, Inactivated microorganisms: rabies, hepatitis A, tick-born encephalitis, poliomyelitis, cholera, plague. Formerly pertussis. Toxoids: tetanus, diphteria

„Modern“ vaccines Subunit: influenza, pertussis Polysaccharide: Heamophilus influenzae B (conjugated), Meningococcus (group A a C, conjugated on non-conjugated), Pneumococcus (conjugate and non-conjugated) Recombinant: hepatitis B Virus-like particles : papillomavirus

„Future (?)“ vaccines Synthetic polypeptides Antiidiotype antibodies DNA vaccines Vector vaccines Antigens inserted into food (bananas, potatoes)

Anti-idiotypic antibodies

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