Function of the Vascular Endothelium after Hypothermic Storage at Four Degrees Celsius in a Canine Tibial Perfusion Model. The Role of Adrenomedullin in.

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Function of the Vascular Endothelium after Hypothermic Storage at Four Degrees Celsius in a Canine Tibial Perfusion Model. The Role of Adrenomedullin in Reperfusion Injury* by TEIJI KATO, ALLEN T. BISHOP, YUAN-KUN TU, and MICHAEL B. WOOD J Bone Joint Surg Am Volume 80(9): September 1, 1998 ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1 Schematic representation showing the sequence of the infusion of the drugs in phase 1 and phase 2 of the study. t1, t2, and t3 indicate the times at which the initial norepinephrine dose-response curve was generated. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 2 Graph of the changes in the mean baseline perfusion pressures (and the standard error of the mean) after storage at 4 degrees Celsius for one, three, five, or seven days. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 3 Graph of the mean concentration (and the standard error of the mean) of endothelin-1 in the venous effluent after storage at 4 degrees Celsius for one, three, five, or seven days. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Figs. 4-A, 4-B, and 4-C: Graphs of the changes in the mean percentage residual response (and the standard error of the mean) to norepinephrine in each group compared with that in the control specimens. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4-B Effect of NG-monomethyl-L-arginine acetate. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 4-C Effect of indomethacin. TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 5 Graphs of the changes in the mean baseline perfusion pressure (and standard error of the mean) after injection with 0.1 milliliter of 10-5-molar adrenomedullin solution or 0.1 milliliter of Krebs-Ringer solution in the tibiae that had been stored at... TEIJI KATO et al. J Bone Joint Surg Am 1998;80: ©1998 by The Journal of Bone and Joint Surgery, Inc.