U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Chapter 8: Contraction and Excitation of Smooth.

Slides:



Advertisements
Similar presentations
Lecture 1 Gastrointestinal Physiology
Advertisements

Muscles and Muscle Tissue: Smooth Muscle Part C2 Prepared by Janice Meeking, W. Rose, and Jarvis Smith. Figures from Marieb & Hoehn 8 th ed. Portions copyright.
LECTURE 21 SMOOTH MUSCLE ANATOMY EXCIT. - CONT. - COUPL.
Smooth Muscle Excitation - Contraction
SMOOTH MUSCLES Dr.Mohammed Sharique Ahmed Quadri Assistant Professor Department Basic Medical Sciences Division of Physiology Faculty of Medicine Almaarefa.
Smooth Muscle Physiology. Muscular System Functions Body movement (Locomotion) Maintenance of posture Respiration –Diaphragm and intercostal contractions.
Muscle Tissue. Introduction Myocyte Cell membrane Cytoplasm Smooth ER Muscle fibre Sarcolemma Sarcoplasm Sarcoplasmic Reticulum.
MUSCLE (skeletal, cardiac & smooth) Systems Biology: Tissue & organ Function Block Lecture 13 10/28/09 1:30-3:00pm Ruben Mestril, Ph.D:
MUSCLE PHYSIOLOGY Ass. Prof. Dr. Emre Hamurtekin EMU Faculty of Pharmacy.
Muscle Physiology:.
WINDSOR UNIVERSITY SCHOOL OF MEDICINE
Anatomy & Physiology I Unit 8: Muscular System Review
Suzanne D'Anna1 Muscular Tissue. Suzanne D'Anna2 Types of Muscle Tissue l skeletal l cardiac l smooth.
Muscle Physiology.
The Muscular System 36-2 BIO 1004 Flora. Types of Muscle Tissue 3 Different Types of muscle tissue: o Skeletal o Smooth o Cardiac o Each type of muscle.
ANNOUNCEMENTS Review Session this Friday: 12:20 Morrill 349 IMAGE523 Poster Team: Let’s Meet After Class Write Abstract Poster Design Discussion: Exam,
Smooth Muscle Characteristics Not striated Dense bodies instead of Z disks as in skeletal muscle Have noncontractile intermediate filaments Ca 2+ required.
Muscular Tissues Department of Biology. Introduction These tissue form the muscle of the body. Composed of muscle cells or muscle fibers (contraction.
Contraction and Excitation of Smooth Muscle
Dr. Ayisha Qureshi MBBS, MPhil Assistant Professor
Muscle Tissue Specialized for contractions Specialized for contractions Elongated cells Elongated cells Unique terms to describe components of muscle.
SMOOTH MUSCLES Dr.Mohammed Sharique Ahmed Quadri Assistant Professor Department Basic Medical Sciences Division of Physiology Faculty of Medicine Almaarefa.
Dr. Mona Soliman, MBBS, MSc, PhD Associate Professor Department of Physiology Chair of Cardiovascular Block College of Medicine King Saud University.
Physiology of Smooth Muscle
Contraction and Excitation of Smooth Muscles Arsalan Yousuf
صدق الله العظيم الاسراء اية 58. By Dr. Abdel Aziz M. Hussein Lecturer of Medical Physiology Member of American Society of Physiology.
Fiber Types Twitch durations vary from 10 to 200 msecs. This variation
Cardiac Muscle Involuntary –heart only Contracts & relaxes continuously throughout life –Contracts without nervous stimulation! –A piece of cardiac muscle.
The Muscular System: Ch
Smooth Muscle  Spindle-shaped cells 2-10  m across & ~100  m long  Have a thin endomysium  Organized into longitudinal and circular layers  Found.
Muscle tissues. Muscle tissue Muscle cells (myocytes) are elongated and classified and or compatible as either striated muscle cells or smooth muscle.
The Muscular System. To return to the chapter summary click escape or close this document.
Muscle Tissue. Three Types of Muscle Tissue Skeletal or Striated Muscle –Makes up all muscles that are attached to bones –Contractions allow the organism.
Smooth Muscle Unstriated muscle associated with visera. (Compare to skeletal muscle) Controlled by autonomic nervous system, hormones and paracrines. actin/myosin.
Muscular and Nervous Tissue Chapter 4.3 Human Anatomy & Physiology.
Visceral Muscle. How is the gut organized anatomically?
Excitation and contraction of smooth muscle
Unit Two: Membrane Physiology, Nerve, and Muscle
Dr. Abdelrahman Mustafa
Non-striated Muscle I. Locations of non-striated muscle in vertebrate body GI tract (including internal, but not external sphincters) Blood vessels and.
X. Smooth Muscle Tissue.
Copyright © 2010 Pearson Education, Inc. Smooth muscle physiology  Organizational structure & function  Excitation contraction coupling.
CH 9 Smooth Muscle Tissue J.F. Thompson, Ph.D.. Smooth Muscle Cells nonstriated = smooth uninucleate.
MUSCLE TISSUE. Muscle Tissue If it contracts, it's muscle: Muscle tissue is categorized on the basis of a functional property: the ability of its cells.
SMOOTH MUSCLE Dr. Ayisha Qureshi MBBS, MPhil Assistant Professor.
Muscle Tissues Prof. Dr. ASHRAF M. Prof. of Histology.
Ch. 4 Part 4 Muscular tissue Nervous tissue. Muscular Tissue Consists of muscle fibers that can use ATP to generate force Function: produces body movements,
Muscle Tissue Specialized for contraction Elongated cells
Dr. Mona Soliman, MBBS, MSc, PhD Associate Professor Department of Physiology Chair of Cardiovascular Block College of Medicine King Saud University.
P.R. Smith, Cell Biology Skeletal Muscle Control.
PowerPoint ® Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R Copyright © 2010 Pearson Education, Inc. 9 Muscles and Muscle.
Contraction Mechanism Actin and myosin interact via to the sliding filament mechanism Resting State –Actin bound by caldesmon –Myosin light chain (MLC)
Smooth Muscle Fibers. Spindle shaped One nucleus Organized into sheets Form the walls of: arteries veins, organs.
MUSCLE SYSTEM Human Anatomy and Physiology. Muscle Tissue  The essential function of muscle is contraction  Three forms: cardiac, smooth, and skeletal.
Types, Properties, Contraction & Relaxation
Muscles and Muscle Tissue P A R T C. Muscle Tone Muscle tone: Is the constant, slightly contracted state of all muscles Keeps the muscles firm, healthy,
Comparison of Properties of: Skeletal, Smooth & Cardiac Muscle Comparison of functional organisation, electrical properties and mechanical properties of.
U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Contraction and Excitation of Smooth Muscle.
Smooth Muscle Physiology
Muscle tissue Specialized for contractility.
Physiology Smooth muscles
Cardiac and Smooth Muscles
Muscular system Part 3: Smooth Muscles.
Contraction and excitation of smooth muscle
Comparative Vertebrate Physiology
Cardiac and Smooth Muscle
Muscular system Part 3: Smooth Muscles.
Dr.Mohammed Sharique Ahmed Quadri
Production of ATP 1. From creatine phosphate.
Skeletal Cardiac Smooth
Presentation transcript:

U N I T II Textbook of Medical Physiology, 11th Edition GUYTON & HALL Copyright © 2006 by Elsevier, Inc. Chapter 8: Contraction and Excitation of Smooth Muscle by Dr. Mudassar Ali Roomi (MBBS, M. Phil.)

Copyright © 2006 by Elsevier, Inc. CLASSIFICATION OF THE MUSCULAR TISSUE Non-striated muscle (smooth muscle) Striated muscle (cardiac, skeletal muscle)

Copyright © 2006 by Elsevier, Inc. SMOOTH MUSCLE No cross striations Location: in the walls of blood vessels, hollow viscera Function: controls the size of the lumen. Shape: each fiber is fusiform in shape. Diameter: 3-8 um Length: um No well developed sarcotubular system. Caveolae are present. Nucleus: single, rod- shaped nucleus located in the centre of each cell.

Copyright © 2006 by Elsevier, Inc. Cytoplasm of smooth muscle fiber E/M shows that actin and myosin are present in the cytoplasm. Actin: diamter is 5-7 nm Myosin: diameter nm actin/myosin ratio: 15/1 Desmin intermediate filaments are also present in the cytoplasm. (dia= 10 nm) Dense bodies: intermediate filaments cross over one another to form darkly staining patches.

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES Location Type of NM Junctions Arrangement Control Membrane potential.

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES 1: LOCATION : UNITARY: Wall of GIT, ureter, bile duct, uterus and large blood vessels. MULTIUNIT: Ciliary muscle of eye, Iris of eye and pilo-erector muscle, vas deference

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES 2: ARRANGEMENT: UNITARY: Sheaths or bundles with gap junctions in between, so act as single unit. If one part is excited  whole is excited.(functinal syncytium) MULTIUNIT: Individual muscle fibers. Each fiber has insulating outer membrane with glycoprotein and collagen consistency. Independently each muscle fiber is excited.

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES 3: TYPE OF NM JUNCTION: UNITARY: Diffuse junction. No contact with nerve fiber. Neurotransmitter is released near the fiber. MULTIUNIT: Contact junction. One of the autonomic nerves form junction with muscle fiber and releases neurotransmitter like nor- epinephrine

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES 4: CONTROL: UNITARY: –Mainly non-nervous stimuli (hormonal stimuli like oxytocin and serotonin). –Nervous stimuli are less important –Show spontaneous contractions. MULTIUNIT: – Mainly through nervous stimuli. – Does not show spontaneous contraction

Copyright © 2006 by Elsevier, Inc. MULTI-UNIT AND UNITARY SMOOTH MUSCLES 5: MEMBRANE POTENTIAL: UNITARY: 3 types: – Spike potential, – Action potential with Plateau and – spikes superimposed on Slow wave. MULTIUNIT: – action potential is not produced. – Only localized depolarization in response to excitation. Types of potential in unitary smooth muscles

Copyright © 2006 by Elsevier, Inc. EXCITATION- CONTRACTION COUPLING OF SMOOTH MUSCLE FIBERS

Copyright © 2006 by Elsevier, Inc. EXCITATION-CONTRACTION COUPLING OF SMOOTH MUSCLE FIBERS

Copyright © 2006 by Elsevier, Inc. Contraction-Relaxation – myosin based regulation Ca 2+ calmodulin MLCK MLC active (phosphorylated) MLC inactive (dephosphorylated) Relaxation Contraction MLCP MLCK, myosin light chain kinase MLCP, myosin light chain phosphatase

Copyright © 2006 by Elsevier, Inc. Mechanisms That Increase Intracellular Ca 2+ Concentration in Smooth Muscle

Copyright © 2006 by Elsevier, Inc.