VERIFICATION OF REFERENCE INTERVALS GIAN LUCA SALVAGNO, MD, PhD University of Verona, Italy.

Slides:

Advertisements

Similar presentations

NORIP, Malmø 27/ NORIP concept Common Nordic Reference Intervals NFKK meeting 27/ Pål Rustad Fürst Medical Laboratory, Oslo

Advertisements

Module 6 “Normal Values”: How are Normal Reference Ranges Established?

Diagnostic Method Diagnosis Diagnosis means `through knowledge` and entails acquisition of data about the patient and their complaints using the senses:

8. Evidence-based management Step 3: Critical appraisal of studies

Help Desk Troubleshooting Computer Problems. 2 Certificate III Software Applications Troubleshooting Computer Problems Solving computer problems is one.

Choosing and Defining a Research Problem Dr. U N Roy Associate Professor, NITTTR Chandigarh Mobile No: Dr U N Roy.

Curriculum mapping. How to make sure the plan comes together David Taylor Liverpool.

Curriculum Evaluation Reverend Dr David Taylor Director of Quality Enhancement School of Medical Education University of Liverpool.

By Dr. Ahmed Mostafa Assist. Prof. of anesthesia & I.C.U. Evidence-based medicine.

Promoting Excellence in Family Medicine Enabling Patients to Access Electronic Health Records Guidance for Health Professionals.

By: Izzy Josheff.  A gerontologist is a medical professional who studies and treats conditions related to the aging process.  Some professionals conduct.

Introduction to the Principles of Laboratory Medicine Photos by Theresa Kristopaitis, MD.

1 GUIDELINES as a way of harmonisation in Europe: Pro’s and Con’s Prof. Dr. Jan. A. Swinkels Psychiatrist Professor in clinical guideline development in.

The Graduate School University of Colorado Anschutz Medical Campus.

Welcome to my presentation on Health Literacy in the Community By Sharon Herring.

Quality Assessment 2 Quality Control.

421 MDS Course Course Director: Dr Asmaa Faden Faden Course Contributors: Prof. A AlDosari.

Predictors of 5-year mortality of 1,323 patients newly diagnosed with clinical type 2 diabetes in general practice With special emphasis on self-rated.

HKAS Assessor Seminar 2006 Technical Assessor Role and Responsibility 28 Feb 2006 Dr Sidney Tam Consultant & Head Division of Clinical Biochemistry Queen.

EVIDENCE BASED MEDICINE Health economics Ross Lawrenson.

Evidence Based Practice

Influence of Analytical Bias and Imprecision on Guideline-Driven Medical Decision Limits Per Hyltoft Petersen Hyltoft Petersen P, Klee GG. Influence of.

Committee Questions Design, Statistical Considerations and Study Conduct 1. There are no clear guidelines regarding the number of people that should be.

The Mediterranean Pediatric FGIDs Project Dr. Elena Scarpato M.D. “Federico II” University of Naples.

BNPCV APCCB BIOLOGICAL VARIATION FOR N-TERMINAL PRO-BNP Jones GRD 1, Bennett A 2,3, Boscato L 1, Macdonald P 2, Brien J 3. Departments of Chemical.

OUTLINE OF HEALTH CARE PLAN RICHARD R. SCHNEIDER, MD F.A.C.P., F.A.C.C.

Evidence-Based Medicine: What does it really mean? Sports Medicine Rounds November 7, 2007.

The Nursing Process ASSESSMENT. Nursing Process Dynamic, ongoing Facilitates delivery of organized plan of nursing care Involves 5 parts –Assessment –Diagnosis.

Virtual Patients with Rules Can adding rules to virtual patients enhance deliberate practice to optimize performance? Tufts University.

Spirometry reference values: a systematic review Turma 1 Docente: Dr. Tiago António Queirós Jacinto Regente: Prof. Dr. Altamiro Pereira INTRODUCTION TO.

Bioequivalence Dr Mohammad Issa Saleh.

VERIFICATION OF BLOOD COLLECTION SYSTEM GIAN LUCA SALVAGNO, MD, PhD University of Verona, Italy.

Evidence-based Policymaking Dr. Shahram Yazdani Shahid Beheshti University of Medical Sciences School of Medical Education Strategic Policy Sessions: 20.

Performance criteria or ”quality specifications” Gunnar Nordin Dubrovnik Course in Zagreb 2015.

Introduction to Clinical Chemistry MLCC-203 Department of Medical Laboratory Technology Faculty of Allied Medical Science By Dr. Eman El-Attar.

Use of Reference Materials in Medical Testing SLAB 10th Anniversary Celebrations Accreditation Conference 10 th November 2015 Dr Deepani Siriwardhana Senior.

Quality control & Statistics. Definition: it is the science of gathering, analyzing, interpreting and representing data. Example: introduction a new test.

Diagnosics by Dr. Zhuoren Lu First Hospital Xian Jiaotong University.

All these theories! How do we apply them? And what do we apply them to? It’s exhausting!

Laboratory Service Health Department in Astana

Various Topics of Interest to the Inquiring Orthopedist Richard Gerkin, MD, MS BGSMC GME Research.

L ABORATORY Q UALITY C ONTROL. INTRODUCTION _A major role of the clinical laboratory is the measurement of substances in body fluids or tissues for the.

Jan 2002 EDMA The central role of the Medical Laboratory in a World of Managed Health An EDMA presentation of the benefits of in vitro testing as a basis.

Source: S. Unchern,  Research is not been completed until the results have been published.  “You don’t write because you want to say something,

Understanding Populations & Samples

Preanalytical variability: turning dark into bright.

Institutional support IN development of Transferable Skills

Critically Appraising a Medical Journal Article

ECVCP Recommendations On Reference Values 2008

Research in Biomedicine and Health – I

Jakub Zawiła-Niedźwiecki University of Warsaw

FAMILY MEDICINE AND LABORATORY TESTS Elham

Chapter 7 The Hierarchy of Evidence

The Anatomy of a Scientific Article: IMRAD format

Reading Research Papers-A Basic Guide to Critical Analysis

Uncertainty in Measurement and Total Error

MGSD Studies Educational study: C. Savona-Ventura (Malta)

CHEN 4903 Introduction.

Study designs used in clinical research

USE OF CLINICAL LABORATORY

Controversial aspects of NORIP

Introduction To Medical Technology

Chapter 18 Evaluator.

Quality Control Lecture 3

Figure 5 Schematic overview of a clinical decision-support

So Many Guidelines, So Little Time:

Quality guidelines on impurities

Quality guidelines on impurities

“Normal Values”: How are Normal Reference Ranges Established?

Centro de P&D UNA-SUS Amazônia/UEA (BRAZIL)

Presentation transcript:

VERIFICATION OF REFERENCE INTERVALS GIAN LUCA SALVAGNO, MD, PhD University of Verona, Italy

THE LABORATORY IN DIAGNOSIS

The aim of a Clinical Laboratory Test is to determine the concentration or activity of a diagnostically relevant analyte in a body fluid in order to provide information on the clinical situation of a patient.

According to Horn and Pesce: “the reference interval is the most widely used medical decision- making tool”, even if its practical usefulness is lower than its theoretical power. This is due to the fact that obtaining a “good” reference interval is a very demanding activity, in terms of time, money and knowledge. In Schneider’s 1960s paper entitled “Some thoughts on normal, or standard, values in clinical medicine”, he states: “… practical medicine is basically founded on comparison. If medicine is to be scientific, we must not only understand the structural, functional and chemical relations operating in individuals, but we must also understand the basis of our comparisons…

Cautions needed in the adoption of traceable reference intervals

HUB Spoke START

Summary of analytical and biological requirements in the adoption of traceable reference intervals in the adoption of traceable reference intervals

“Which is the best choice?” Or……

EXCLUSION CRITERIA

EXEMPLE OF PARTITIONING FACTORS

PRE-ANALYTICAL FACTORS FOR CONSIDERATIONS

What’s next?

…and I am ready to start!

The End

Take a home message Reference intervals “is an interval that, when applied to the population serviced by the laboratory correctly includes most of the subjects with characteristics similar to the reference group and excludes the others” (Ceriotti F. Prerequisites for use of common reference intervals. Clin Biochem Rev. 2007;28: ). It has been recommended that an Reference Intervals be established by selecting a statistically enough group of healthy people. Clinical laboratory professionals, who want to provide a high quality report, should comply with the requests of quality standards like ISO 15189:2012, which specifically asks for a periodical review of biological reference intervals.