Cell Membranes
Cell Membrane Views
Phospholipid Molecule
Hydrophilic and Hydrophobic Molecules interacting differently with water
Wedge-shaped lipids form micelles Cylinder-shaped lipids form bilayers
Spontaneous sealing of phospholipid bilayer
Liposomes
Phospholipid mobility
Cis-double bonds affect packing
Cholesterol glycolipids
Function of Cholesterol
Phospholipid types
Microdomains on plasma membrane Lipid rafts Choresterol sphingolipids
Asymmetrical distribution of phospholipids and glycolipids
Phospholipids in cell signaling
Phospholipase Cleavage sites
Glycolipids
Membrane Proteins
Membrane Proteins
Fatty acid chain or prenyl group modifications
Hydropathy Plots
B-barrel membrane proteins
Membrane proteins are glycosylated
A detergent micelle
Solubilize membrane proteins with detergent
Detergents
Mild detergent for the solubilizing, purification, and reconstitution of membrane protein functions
SEM image of red blood cells
The preparation of red blood cell membranes
15 major membrane proteins in red blood cells
Membrane proteins are diffusable
Proteins restrictions
Protein distributions in a guinea pig sperm cell
4 ways of protein restrictions
Carbohydrate layer (Glycocalyx) on the cell surface
Diagram of glycocalyx
Summary Phospholipids, cholesterol, glycolipids for membrane Asymmetric, inner and outer monolayer subcompartments and lipid functions in cell signaling membrane proteins and their anchoring models diffusion, distribution glycocalyx, proteoglycan
Membrane Transport of Small Molecules and the Electrical Properties of Membranes
Permeability of plasma membrane
Carrier Protein and Channel Protein
Transportation Models
Electrochemical Gradient
Ionophores
Conformational change of a carrier protein
Kinetics of simple and carrier-mediated diffusions
3 ways of driving active transportation
3 types of carrier-mediated transport
Coupled transportation of glucose and Na+
Transcellular transport
Na+-K+ Pump, ATPase
Cycles of Na+-K+ Pump
Functions of Na+-K+ Pump
ABC transporter 2 ATP-binding cassette domains
A typical Ion Channel
The gating of Ion Channels
The Structure of bacterial K+ channel
Gating Model of K+ channel
Summary Membrane transportation, carrier protein, channel protein Active transportation, passive transportation ATPases, Na+-K+ Pump Gating mechanisms of Ion Channels, K+ channel selectivity