Expanding the Capacity for Comparative Effectiveness Research

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Presentation transcript:

Expanding the Capacity for Comparative Effectiveness Research Carolyn Clancy, MD Director U.S. Agency for Healthcare Research and Quality AcademyHealth Annual Research Meeting Orlando – June 3, 2007

Research Needs Gaining Increased Attention

Rationale for Evidence-Based Medicine Maximize the likelihood that beneficial treatments are used and that harmful treatments are not used Reduce costs and/or improve cost effectiveness Provide an explicit, fair and rational method of resource allocation

Why do we Need Effectiveness Research? Not all interventions that sound “logical” are beneficial when carefully studied Not all beneficial interventions are equally beneficial, or equally safe Budgets are limited Issues are complex and cannot be clarified without careful analysis

The Intersection of Effectiveness and Safety Effectiveness – Benefits

The Intersection of Effectiveness and Safety Safety – unintended consequences, harms

The Intersection of Effectiveness and Safety Balance of Benefits and Harms

Agency for Healthcare Research and Quality Performance Accountability, Resources & Technology Communication & Knowledge Transfer Extramural Research, Education & Priority Populations Center for Financing, Access & Cost Trends AHRQ Center for Primary Care, Prevention, Partnerships Center for Delivery & Organization & Markets Center for Quality Improvement & Patient Safety Outcomes & Evidence Effective Health Care

Effective Health Care Program Evidence Synthesis (EPC program) Systematically reviewing, synthesizing, comparing existing evidence on treatment effectiveness. Identifying relevant knowledge gaps. Evidence Generation (DEcIDE, CERTs) Development of new scientific knowledge to address knowledge gaps. Accelerate practical studies. Evidence Communication/Translation (Eisenberg Center) Translate evidence into improvements Communication of scientific information in plain language to policymakers, patients, and providers.

New Effective Health Care Web site http://effectivehealthcare.ahrq.gov/

AHRQ Comparative Effectiveness Reviews (CERs) Comparative Effectiveness of Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression - 1/24/2007 Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics - 1/17/2007 Comparative Effectiveness of Management Strategies for Renal Artery Stenosis - 10/24/2006 Comparative Effectiveness and Safety of Analgesics for Osteoarthritis - 9/25/2006 Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment - 5/23/2006 Effectiveness of Noninvasive Diagnostic Tests for Breast Abnormalities - 2/9/2006 Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease - 12/13/2005

AHRQ Focuses on the Health Care System Assess the effectiveness, comparative effectiveness and cost- effectiveness of health care services Identify ways to improve patient safety and quality of health care systems Advance the appropriate use of health information technology Understand system issues: role of organizational design, management, workflow, management, and incentives on efficiency and effectiveness Develop data on the health care system for monitoring and decision-making

Questions & Comments?