Detection of Ziram by LC/APCI/MS Hiroshi MORIWAKI

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Presentation transcript:

Detection of Ziram by LC/APCI/MS Hiroshi MORIWAKI Osaka City Institute of Public Health & Environmental Sciences

Ziram use toxicity pesticide antifouling agent endocrine disruptor ((CH3)2NCS.S)2Zn M.W. 305.8 m.p. 240 Log Pow 1.09 endocrine disruptor mutagen carcinogen

Analysis of Ziram × Conventional method Direct detection by GC/MS　→　× Conventional method Decomposition of the ligand to CS2 × Chemical speciation of dithiocarbamate pesticides LC/MS ( Direct detection of ziram )

Ion mode Ionization Positive ion mode Negative ion mode ESI/MS × × APCI/MS × Corona current<0.6mA × ○ Corona current>0.6mA

Mass spectrum B) A)

Corona current vs. peak intensity

Cone voltage vs. peak intensity

Conditions of APCI/MS

Column separation

Mass chromatogram

Calibration curve

Summary Next step ・ Direct detection of Ziram by LC/APCI/MS ・ Corona current > 0.6mA ・ LC separation: GPC column ・ Instrumental detection limit: 2mg/L Next step ・ Development of the pretreatment ・ Use of LC/MS/MS ref. H. Moriwaki, Y. Yamaguchi and M. Fukushima: Rapid Commun. Mass Spectro., in press (2001).