Gene Ontology Project

Slides:

Advertisements

Similar presentations

NIH T-32 Application Ruth L. Kirschstein National Research Service Award Institutional Research Training Grants

Advertisements

Office of Science Education National Institutes of Health Department of Health and Human Services Introduction to the National Institutes of Health.

What’s NIH? National Cancer Institute National Eye Institute National Heart, Lung, and Blood Inst. National Human Genome Research Inst National Institute.

FY 2012 NIH Budget Roll-out Francis S. Collins, M.D., Ph.D. Director, NIH.

NIH Academic Research Enhancement Award (AREA) R15 AASCU November 5, 2009 Mary Ann Guadagno, PhD Office of Extramural Research National Institutes of Health.

Expiring Funds April Update SAC Meeting April 24, 2013.

Office of Research Support.  Departmental Grant Manager – Enters information into SPS.  Sponsored Projects System (SPS) is where Grant Managers can.

NIH F-31 Application Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related.

SSG Grant writing club, March  What is a K99 and reasons to write a K99 / R00  NIH information  UAB help  My own experience  13 things I wish.

National Institutes of Health K awards Margie Lee Dept Population Health BHSI Fellowship Writing Workshop Phase 1 – Feb 5, 2011.

American Evaluation Association EVALUATION 2011 November 3, 2011 Approaches to Biomedical Research and Development Portfolio Analysis: Examples From the.

ACADEMIC RESEARCH ENHANCEMENT AWARD AREA (R15) Paula Flicker.

Demonstration Trupti Joshi Computer Science Department 317 Engineering Building North (O)

Weathering the Storm: How to Establish and Sustain an Independent Research Career in an Era of Limited Funds Lawrence J. Prograis, Jr., M.D Senior Scientist,

Grant Writing Introduction  Overview of Grantwriting  NIH.

U.S. Department of Health and Human Services National Institutes of Health National Heart, Lung, and Blood Institute James P. Kiley, Ph.D. National Heart,

Page Rankings: What do they teach us? Faina Linkov, PhD Ronald LaPorte, PhD And the Global Health Network Supercourse project University of Pittsburgh.

NIH OBSSR Summer Institute July 2012 National Institutes of Health U.S. Department of Health and Human Services Overview of the NIH Peer Review Process.

NIH K-08 Application Mentored Clinical Scientist Research Career Development Award

Gene Ontology Project

Short Overview of the NIH SBIR/STTR Program “Lab to Life”

Bethesda, MD. NCI National Cancer Institute NCCAM National Center for Complementary and Alternative Medicine NCMHD National Center for Minority Health.

The R21 Mechanism. Your guide through the R21 jungle* Patricia Parmelee, PhD (Pat to you) * jun’ gle, n.: a confused or disordered mass of objects; something.

NCRR American Society of Plant Biologists NIH Science Education Partnership Award (SEPA)

Mouse; NOTC1; Q01705 Function: protein binding Process: Notch signaling pathway Process: positive regulation of transcription from RNA polymerase II promoter.

NIAID Commitment to Influenza Research and Preparedness F. Gray Handley Associate Director for International Research Affairs National Institute of Allergy.

Office of the Director National Institute on Alcohol Abuse and Alcoholism National Institute on Alcohol Abuse and Alcoholism National Institute of Arthritis.

Gene Ontology (GO) Project

NIH Investment in the Science of Learning Robert M. Kaplan NIH Associate Director for Behavioral and Social Sciences Sabrina Liao Geehta Senthil Office.

NIH International Programs

The Review of Your NIH Grant Application Begins Here Richard Nakamura, Ph.D. Director NIH Center for Scientific Review.

NIH K-01 Application Mentored Research Scientist Development Award

Only build an ontology if: You have a body of data to annotate.

American Evaluation Association EVALUATION 2009 November 14, 2009 Building Data Systems to Support Evaluation in a Biomedical Research and Development.

Innovation Corps (I-Corps) at NIH: Hypothesis-Driven Customer Discovery for SBIR/STTR Grantees Bench 2 Business (B2B) – University of Kentucky May 19,

The Grant Renewal Review Process Nywana Sizemore, PhD Scientific Review Officer Molecular Oncogenesis - MONC Oncology I - Basic Translational - OBT Integrated.

National Institutes of Health. Much of the biomedical research in the United States is supported by the Federal Government, primarily the National Institutes.

Jo Anne Goodnight NIH SBIR/STTR Program Coordinator NIH Mission Improve human health through biomedical and behavioral research, research training and.

NIH Grant Renewal Review Process (and Beyond)

Gene Ontology Project

NIH Peer Review Process – Grant Renewal

Center for Scientific Review (CSR). Office of the Director National Institute on Alcohol Abuse and Alcoholism National Institute on Alcohol Abuse and.

1 ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES PRESENTATION San Antonio Texas September 24 – 26, 2007.

An Overview of Peer Review at CSR – Critical Do’s and Don’ts Joy Gibson, D.Sc. Director, Division of Translational and Clinical Sciences American Association.

BME 301 Lecture Twenty-Three. How are health care technologies managed? Examples: MRI Laparoscopic cholecystectomy Vitamin C treatment for scurvy Research.

NIH F-32 Application Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellowships

1 Academic Research Enhancement Award (AREA) Program Erica Brown, PhD NIH AREA Program Director NIH Regional Seminar Scottsdale, Arizona April 28, 2011.

FY 2011 Acquisition Charts CHART 1 - Displays total NIH FY 2011 acquisitions in dollars. It is divided into the seven components of acquisition at the.

The Search for a “Better Way:” Reauthorization of the National Institutes of Health Elias A. Zerhouni, M.D., Director, NIH July 19, 2005 House Energy and.

National Institute of Biomedical Imaging and Bioengineering Richard E. Swaja, Ph.D. National Institute of Biomedical Imaging and Bioengineering BERAC –

The NIH Funding Process Peggy McCardle, PhD, MPH Child Development & Behavior Branch National Institute of Child Health & Human Development We wish to.

NIH Peer Review Process – Grant Renewal Angela Y Ng, MBA, PhD Scientific Review and Referral Officer Center for Scientific Review NCI DCB New Grantee Workshop.

Expired Funds SAC March 26, 2014 Cristy Perrin, OALM.

1 AIRI Statistics – Trends in NIH Awards Presented at Association of Independent Research Institutes (AIRI) 2008 Annual Meeting September 10, 2008, Washington,

Data provided by the Division of Information Services, Reporting Branch NATIONAL INSTITUTES OF HEALTH (NIH) DATA BOOK Fiscal Year 2010.

Gene Ontology TM (GO) Consortium

Office of Research Support.  Departmental Grant Manager – Enters information into SPS.  Sponsored Projects System (SPS) is where Grant Managers can.

Organizational Funding Portfolios and Beyond: Assessing the Full Research Landscape Panel Session 731 American Evaluation Association EVALUATION 2012 October.

How to get funded from the National Institutes of Health Minda R. Lynch, Ph.D., Chief Behavioral and Cognitive Science Research NIDA.

Jeanne McDermott, PhD,MPH,CNM Program Officer Division of International Training and Research Fogarty International Center National Institutes of Health.

NIH HIV/AIDS Research Priorities

The Gene Ontology Project

American Evaluation Association

The Influence of Domain-Specific Metric Development on Evaluation and Design: An Example from National Institutes of Health Technology Development Programs.

NIH F Applications and You

“How Can Providers Address the Lack of R01 Studies. ” Robert H

NIH Predoctoral Fellowship Information Session

NIH Predoctoral Fellowship Information Session

National Institutes of Health

Overview of the Health & Human Services SBIR/STTR Programs

Presentation transcript:

Gene Ontology Project

Clark et al., 2005 part_of is_a

Clark et al., 2005

Who uses GO?

1.National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2.National Institute on Aging (NIA) 3.National Institute of Allergy and Infectious Diseases (NIAID) 4.National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5.National Center for Complementary and Alternative Medicine (NCCAM) 6.National Cancer Institute (NCI) 7.National Institute on Drug Abuse (NIDA) 8.National Institute on Deafness and Other Communication Disorders (NIDCD) 9.National Institute of Dental & Craniofacial Research (NIDCR) 10.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 11.National Institute of Biomedical Imaging and Bioengineering (NIBIB) 12.National Institute of Environmental Health Sciences (NIEHS) 13.National Eye Institute (NEI) 14.National Institute of General Medical Sciences (NIGMS) 15.National Institute of Child Health and Human Development (NICHD) 16.National Human Genome Research Institute (NHGRI) 17.National Heart, Lung and Blood Institute (NHLBI) 18.National Library of Medicine (NLM) 19.National Center on Minority Health and Health Disparities (NCMHD) 20.National Institute of Mental Health (NIMH) 21.National Institute of Nursing Research (NINR) 22.National Institute of Neurological Disorders and Stroke (NINDS) 23.National Center for Research Resources (NCRR) 24.Fogarty International Center (FIC) Sample of 77 research papers, both intra-mural & extra-mural research. NIH funded experimental research that uses the GO

Companies NLP & Ontology Products BioWisdom, IBM Array Products and data analysis Affymetrix, Spotfire Products that use GO Clontech, Inpharmatica Reagents & services Sigma, Abnova Big Pharmas AstraZeneca

Publications Published articles mentioning GO = 1063, in 284 journals Google Scholar ‘gene ontology, tool for unification of biology’ 1291 citations 25th September 2006

publications over 284 Journals Who is citing GO?

Mitochondrial P450 ( CC24 PR01238; MITP450CC24) Annotation

GO cellular component term: mitochondrial inner membrane ; GO: Where is it? Mitochondrial p450

GO molecular function term: monooxygenase activity ; GO: What does it do? substrate + O 2 = CO 2 +H 2 0 product

GO biological process term: electron transport ; GO: Which process is this?

monooxygenase activity ; GO: Other gene products: MGImonooxygenase, DBH-like 1 MGIprostaglandin I2 (prostacyclin) synthase MGIsplicing factor 3b, subunit 2 SGD flavin-containing monooxygenase TAIR FERULATE-5-HYDROXYLASE 1

Cell type ontology

Whole genome analysis (J. D. Munkvold et al., 2004)

attacked time control Puparial adhesion Molting cycle hemocyanin Defense response Immune response Response to stimulus Toll regulated genes JAK-STAT regulated genes Immune response Toll regulated genes Amino acid catabolism Lipid metobolism Peptidase activity Protein catabloism Immune response Bregje Wertheim at the Centre for Evolutionary Genomics, Department of Biology, UCL and Eugene Schuster Group, EBI. …analysis of high-throughput data according to GO MicroArray data analysis