Meeting of the Working Group on TB Drug Development Why you need to be engaged? Marcos Espinal Executive Secretary Stop TB Partnership 29 October 2004 Paris, France

I am pleased to let you know that… tuberculosis control has progressed to the point where virtual elimination of the disease as a public health problem appears to be within reach… So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please go home, relax, and look for a more exciting job… November 1959, The Arden House Conference on Tuberculosis. New York The Arden House Conference on Tuberculosis. U.S. Department of Health, Education, and Welfare, Public Health Service No Washington, DC:US Government Printing Office; 1961.

Stop TB Goals By 2005 By 2005 – 70% Case detection under DOTS – 85% Cure rate By 2015: Millennium Development Goals By 2015: Millennium Development Goals – 50% reduction in prevalence and deaths by 2015 By 2050:The global incidence of TB disease will be less than 1 per million population By 2050:The global incidence of TB disease will be less than 1 per million population New tools will take us there New tools will take us there

Challenges Additional resources for health and poverty reduction – – Workforce crisis: more & better human resources – – Better harmonized and more effective aid – – Strengthened health systems: primary care – – Improved performance monitoring Consolidate, sustain and advance achievements – – Mobilise communities, the private sector, and enhance political commitment – – Accelerate response to HIV/AIDS emergency – – Invest in research & dev't to shape the future Source: 2 nd Ad-hoc committee, September 2003

Partnership towards Stop TB Targets Partners Forum Coordinating Board Secretariat/GDF Goals & Targets DOTS Expansion WG TB/HIV WG DOTS-Plus MDRTB WG New Drugs WG TB Diagnostics WG New Vaccines WG Communication/ Advocacy WG

WG Mission You need to deliver faster and affordable TB medicines – Simplification / shortening TB treatment – Improve latent TB treatment – Effective against MDR-TB – Be easily adoptable in the field

Why is important for the R & D community to keep engaged through the WG… Current tools are not sufficient and being away and isolated is not the solution MGIT …. About years….

Portfolio Shared responsibility Shared responsibility – Novartis donation to GDF – Eli Lilly discount to the GLC Networking Networking – Learning from others – duplication Forum for a common agenda on new tools issues Forum for a common agenda on new tools issues – economics, regulatory requirements, trial site register, immunological issues, market introduction, advocacy and communication Get new tools into TB control in poor countries Get new tools into TB control in poor countries – Cross fertilization with other WGs Global Plan to Stop TB Global Plan to Stop TB

DOTS Expansion Working Group: DOTS Expansion Working Group: 180 countries implementing DOTS Working Group on TB/HIV: Working Group on TB/HIV: Policy for TB/HIV collaborative activies Working Group on DOTS- Plus for MDR-TB: Working Group on DOTS- Plus for MDR-TB: Treatment for MDR-TB in more than 10 countries The Global Plan to Stop TB (and 2003 update) Working Group on New Diagnostics: Working Group on New Diagnostics: Enabling environment for commercial tool development Working Group on New TB Drugs: Working Group on New TB Drugs: Pipeline of promising compounds Working Group on New Vaccines: Working Group on New Vaccines: Two vaccine candidates entering phase I clinical trials

Partnership Governance: Coordinating Board High TB burden countries (4): China, India, Brazil, DR Congo High TB burden countries (4): China, India, Brazil, DR Congo Regional representatives (6) Regional representatives (6) WHO, World Bank, UNAIDS, GFATM WHO, World Bank, UNAIDS, GFATM Working Group Chairpersons (7) Working Group Chairpersons (7) Financial donors (4): CIDA, Japan, Euro (NL), USAID Financial donors (4): CIDA, Japan, Euro (NL), USAID Foundations (1): Gates Foundation Foundations (1): Gates Foundation NGOs and technical agencies (3): IUATLD, CDC, IFRC NGOs and technical agencies (3): IUATLD, CDC, IFRC Communities affected by TB (1): Under selection Communities affected by TB (1): Under selection Chair of the WHO STAG: Mexico vice MOH Chair of the WHO STAG: Mexico vice MOH Corporate business sector: Heineken Corporate business sector: Heineken

I am pleased to let you know that… tuberculosis control will progress to the point where elimination of the disease as a public health problem will be within reach… So Maria, Peter, Giorgio, Rick, Ken, Lee, and all of you please keep working hard because the quest is not yet over…

Thank you… …for your contributions, and your continued collaboration in the Stop TB Partnership!