The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems  Prof. Charles A. DiMarzio  Northeastern University Portable Skin Cancer Microscope.

Slides:

Advertisements

Similar presentations

Lasers ….how old are they? Peter Blood Cardiff University.

Advertisements

Scanning Confocal Basics n What’s so special ? n Confocals give higher resolution than normal microscopes. n Confocals can OPTICALLY SECTION a sample.

Comparison and Implications of Three Optical Microscopy Data Acquisition Modalities James Butler Ph.D. Nikon Instruments, Inc. Widefield Fluorescence Confocal.

Spectral Self-interference Fluorescence Microscopy in 4Pi Mode Mehmet Dogan, Lev Moiseev, Stephen B. Ippolito, Anna K. Swan, Bennett B. Goldberg, M. Selim.

Spectroscopy is the study of interactions between light and matter. Photoinduced absorption spectroscopy can show us which materials (such as quantum dots)

1 Swept Source Frequency Domain Optical Coherence Tomography Swept Source Frequency Domain Optical Coherence Tomography Anurag Gupta University of Rochester,

Optical Coherence Tomography

Photonics Center NSF REU INM – June 9, 2015 EEC ‐ Boston University Photonics Center National Science Foundation Research Experiences for Undergraduates.

The Outreach Project “Helping NW companies access fund for R&D” Lesley Lambert General Engineering Research Institute Liverpool John Moores University.

September 2003 Chuck DiMarzio, Northeastern University Introduction Charles A. DiMarzio GEU110 Northeastern University.

FIBER OPTIC RS-OCT PROBE Team Members: John Acevedo Kelly Thomas Chris Miller Advisors: Dr. Patil Dr. Mahadevan-Jansen.

Optical Microscopy Widefield Microscopy - Brightfield, Darkfield, DIC, Phase Contrast, Fluorescence … Total Internal Reflection (TIR and TIRF) Microscopy.

Zoology I Cytology, Embryology & Histology By Dr/ Alyaa Ragae Zoology Lecture Faculty of Oral and Dental Medicine Future University.

The mission of the ONS Foundation is to support oncology nursing to improve the lives of people with or at risk for cancer.

LLNL-PRES This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract.

Photo-Thermal Coherent Confocal Microscope This work is supported in part by the Center for Subsurface Sensing and Imaging Systems, under the Engineering.

Articulating Confocal Endoscope for Imaging Cancers in vivo This work is supported in part by the Center for Subsurface Sensing and Imaging Systems, under.

Confocal Reflectance Theta Line-Scanner for Intra-operative Imaging Confocal Reflectance Theta Line-Scanner for Intra-operative Imaging Peter J. Dwyer*,

September 2003 Chuck DiMarzio, Northeastern University An Example Charles A. DiMarzio GEU110 Northeastern University.

Program will begin shortly… “Inner Life of the Cell”, Harvard University © 2008 Up Next … Making Molecular Movies with Up Next … Making Molecular Movies.

The above shows the implementation of the software used to interface with the data acquisition hardware. Inputs for each encoder and the APD detector were.

Microscopy Observing microorganisms. Light microscopy – any microscope that uses visible light.

Multi-Spectral Reflectance Confocal Microscopy on Skin Tianchen Shi, Prof. Charles A. DiMarzio Department of Electrical and Computer Engineering, Northeastern.

David Sampson School of Electrical, Electronic, & Computer Engineering.

The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems Charles V. Stewart Dept. of Computer Science Rensselaer Poly. Inst. CenSSIS Charles.

Terahertz Applications for Detection of Explosives Jian Chen, Yunqing Chen, Hongwei Zhao, X.-C. Zhang Center for Terahertz Research, Rensselaer Polytechnic.

May Chuck DiMarzio, Northeastern University ECE-1466 Modern Optics Course Notes Part 7 Prof. Charles A. DiMarzio Northeastern University.

Tao Yuan, Jingzhou Xu, and Xicheng Zhang Rensselaer Polytechnic Institute, Troy, New York Scanning THz Emission Microscope Abstract A THz image system.

Unit 5, Chapter 15 Integrated Science. Unit Five: Light and Optics 15.1 Seeing an Image 15.2 The Human Eye 15.3 Optical Technology Chapter 15 Optics.

National Science Foundation Materials for Optical Properties by Design at the UV Range Leah Bergman, University of Idaho, DMR Outcome: The researchers.

Using Multi-Element Detectors to Create Optimal Apertures in Confocal Microscopy This work was supported in part by CenSSIS, the Center for Subsurface.

February 2004 Chuck DiMarzio, Northeastern University a-1 ECEU692 Subsurface Imaging Course Notes Part 2: Imaging with Light (3): Strong Scattering.

Microscope Instrument used to make very small objects appear larger.

The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems BomDetec: Wide Area Surveillance and Suicide Bomber Detection at Greater than.

Research Overview Bahaa Saleh Carey Rappaport David Castañón Badri Roysam Miguel Velez-Reyes David Kaeli Research Overview Bahaa Saleh Carey Rappaport.

Summarized by: Name: AGNES Purwidyantri Student ID No: D

Suppression of the eyelash artifact in ultra-widefield retinal images Vanessa Ortiz-Rivera – Dr. Badrinath Roysam, Advisor –

Engr College of Engineering Engineering Education Innovation Center Engr 1182 Nano Pre-Lab Demolding Rev: 20XXMMDD, InitialsPresentation Short.

January 2004 Chuck DiMarzio, Northeastern University ECEU692 Subsurface Imaging Course Notes Part 3: Imaging with Light (2) Hyperspectral Imaging.

Scanning Electron Microscopy

Gordon-CenSSIS/NE-LSAMP 2007 Research Experiences for Undergraduates (REU) Program Application Instructions Due date: March 23, 2007Page 1 This work was.

February 2004 Charles A. DiMarzio, Northeastern University ECEG287 Optical Detection Course Notes Part 10: More on the Detector as a Circuit.

Optical microscope Optical microscopes are compound microscopes ▫Occular lens ▫Optical lens Light passes through the specimen. Different areas absorb different.

Imaging HIFU Lesions Using Ultrasound Andrew Draudt and Robin Cleveland Department of Aerospace and Mechanical Engineering, Boston University, Boston,

Challenges and Opportunities Currently most pulsed THz systems are based on Ti-Sapphire laser systems with ZnTe crystals as THz emitters and detectors.

Backprojection and Synthetic Aperture Radar Processing on a HHPC Albert Conti, Ben Cordes, Prof. Miriam Leeser, Prof. Eric Miller

June 17, 2005 Holiday InnRussellville, Arkansas Departmental Report and Special Projects Joseph J. Rencis, Professor and Head Arkansas Academy of Mechanical.

Ball Aerospace & Technologies Corporation -

Photoacoustic Tomography The Future Of Medical Imaging Techniques

CD and DVD Technology using laser light to reproduce music and movies.

Date of download: 5/28/2016 Copyright © 2016 SPIE. All rights reserved. Optical and electronics design of a laser reflectance confocal microscope (VivaScope).

Advanced Confocal Microendoscopy Wibool Piyawattanametha, Ph.D.

Karissa Thoma: Co-leader Tuan Tran: Co-leader Susie Samreth: BSAC Peter Kleinschmidt: Communicator Vidhya Raju: BWIG Prof. Walter Block (BME): Advisor.

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. (a) Schematic of the luminescence acquisition setup and the geometry of the flat.

10fs laser pulse propagation in air Conclusion The properties of femtosecond laser pulse propagation over a long distance (up to 100m) were studied for.

Chapter 3 Cell Structure. Section 1 Looking at Cells Most Cells are too small to see with the naked eye. Term coined by Robert Hooke after looking at.

Light Microscope.

OUR DEPARTMENT One of the country’s oldest BME programs

Background With new accelerators delivering beams always smaller and more energetic, requirements for very precise beam alignment become more and more.

Plans for 2011 Steven James January 22, 2011

Lecture 17: Guest Lecture Professor Gordon Wetzstein

HyperSpectral Skin Imaging Tianchen Shi, Prof. Charles A. DiMarzio

Point Detector Aperture

Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study Heidy Sierra, Miguel Cordova, Chih-Shan Jason Chen, Milind Rajadhyaksha

Small delights Current Biology Volume 18, Issue 7, (April 2008)

Diffraction and Resolution

Misbah Huzaira, Francisca Rius, Milind Rajadhyaksha, R

Fig. 2. The structure of a binocular depth perception system1.

Salvador González, Robert Sackstein, R

Theoretical Background Challenges and Significance

Presentation transcript:

The Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems  Prof. Charles A. DiMarzio  Northeastern University Portable Skin Cancer Microscope Product Development This work was supported by in part by the Gordon Center for Subsurface Sensing and Imaging Systems, under the Engineering Research Centers Program of the National Science Foundation (Award # EEC ). 5 Million Biopsies for 1 Million Cancers!

Example of Current Confocal Microscope Technology 25  m - VivaScope Sub-Cellular Resolution - Imaging to DE Junction - Large Package - Limited Flexibility

Next Generation: NU Work  Get the Light from the Microscope to the Patient and Back  Make the Microscope Smaller

Articulated Arm and Endoscope Gustavo Herrera (BS 2003, MS 2005), Milind Rajadhyaksha, Gary Peterson (BS, 2007) Multiple Wavelengths: 532 nm, 830 nm, and 1064 nm √ See Poster (capstone)

Theta Line Scanner Peter Dwyer (BS 1989, MS 1997, Ph.D. 2005), Milind Rajadhyaksha Confocal in One Direction, but Not in the Other for Greater Speed. Bistatic for Improved Sectioning. -Dwyer, Peter J., Charles A. DiMarzio, James M. Zavislan, William J. Fox, and Milind Rajadhyaksha, “Confocal Reflectance Theta Line--Scanning for Imaging Human Skin in vivo,” Optics Letters, Dwyer, P. J., C. A. DiMarzio, and M. Rajadhyaksha, ``Confocal theta line-scanning microscope for imaging human tissues,”Appl. Opt. 46, 1 April Pp

Dual Wedge Confocal Microscope Initial Development P1P1 P2P2 αα θ1θ1 θ1θ1 θ2θ2 Bill Warger (MS 2005, Ph.D. Candidate), and Many Undergraduate Students (Capstone Design Winner in 2004) √ See Poster

Dual Wedge Confocal Microscope Recent Work 100 µm Upgraded Acquisition System to Achieve Integration time in Seconds rather than Minutes. Operational Goal is 1/5 Second Imaging of Business Card and Plant Material Shows Sectioning and Resolution √ See Poster Design Goal

Dual-Wedge Cofocal Microscope Product Development Plan  Submit Proposals  NIH STTR (Close Score)  R01 “Industry-University Partnerships... Imaging for Cancer Investigations”  Submit Paper on Resolution (Done)  Demonstrate Skin Imaging with Sub- Cellular Sectioning and Resolution  Develop Intermediate Generation System (Gordon Fellowship?)  Demonstrate Feasibility, and then Design Hand-Held Instrument