Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

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Presentation transcript:

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells VEGF, Notch

Vasculogesis and angiogenesis in vertebrates

Models Intussuseptive angiogenesis (tissues as muscle, often blood flow dependent etc.)

Angiogenesis is a dynamic and context determined process

Examples of vascular defects

Integrins in the vasculature

L1CAM A7Lm68% embryonic lethal hemorrgaged E SM cells

Integrin inhibitors and RTK agonistic interactions (Kaan)

Angiopoitins, Tie1 and Tie2 receptor

PDGF RTK signaling

VEGF RTK signaling

VEGFR3 at tips cells

Signaling in sprouting tip cells

Delta-Notch signaling

Sema3 inhibits integrin function. Normal angiogenesis… semaphorins

Mouse models affecting TGFbeta signaling

Haemodynamics affect vascular remodelling example

Pixt2 KO phenotypes in 6th BAA Occlusion of right BAAs results in Persistence of left 6 BAA