Robert Scranton© 2008. 5 Cardinal Signs of Inflammation Heat Redness Swelling/ Edema Pain Loss of Function Vascular Dilation Exudate Afferent Information.

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Presentation transcript:

Robert Scranton© 2008

5 Cardinal Signs of Inflammation Heat Redness Swelling/ Edema Pain Loss of Function Vascular Dilation Exudate Afferent Information A result of the edema and pain Caused By?

Inflammation Acute Chronic Neutrophil No Neutrophil Lymphocytes, monocytes, eosinophils Yes Lymphocytes (also macrophages) Cell type: Angiogenesis: Hallmark:

Inflammation Mast Cell Neutrophil IgE Heparin, Histamine & SRS-A Around small bv, external epithelia IgG & complement Primary granules= Lysozyme & myeloperoxidase Secondary Granules= alkaline phosphatase Tertiary Granules= gelatinase intravascular Receptor: Contents Location

Special Neutrophil info Life span? When dead after responding to inflammation, they become? How do neutrophils survive in devascularized tissue? Explain the process by which they get into the area of inflammation.

Margination

Rolling

Diapedesis

Macrophage Derived from? Surface receptor types? Activated macrophages look ________. What happens when many macrophages surround large foreign bodies? Functions

Lymphocytes Nuclear/cytoplasmic ratio? Cell mediated=? Humoral= ?

Eosinophils Phagocytic activity Surface receptors for? How does it attack parasites? Granules, what type?

=

Basophils Receptors for Discuss slow and fast granule release Granules contain?

Reconstruction Days? Fibroblasts+ vascular endothelial cells= ? What are the characteristics of granulation tissue? What happens after reconstruction? Primary v. secondary union

Remodeling Time period Typical maximal tensile strength of the CT is?