Antigen Presenting Cells

Slides:

Advertisements

Similar presentations

Antigens & HLA Dr.Ghada Boghdadi.

Advertisements

Immunogen vs Antigen immunogen induces immune response antigen reacts with products of the immune response immunogenicity –nature of the immunogen –ability.

DEPARTMENT OF IMMUNOBIOLOGY Antigens (Ag) Xiaowu Hong Department of Immunology Shanghai Medical College of Fudan University.

IMMUNOLOGY Ms. Lucky Juneja Lecturer, School of Biotechnology, DAVV.

Antigens. Definitions Immunogen Immunogen Antigen (Ag) Antigen (Ag) Hapten Hapten Epitope or Antigenic Determinant Epitope or Antigenic Determinant Antibody.

Antigens Where we’re going- Immunogenicity vs antigenicity

Eugene P. Mayer Office: Bldg. #2, Rm. B19 Phone:

Pattern recognition in the immune system. Specific peptide recognition Antibody epitopes T-cell receptors recognizing peptides presented on MHC-molecules.

Immunology Overview. Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement.

General Microbiology (Micr300)

Principles of Immunology Antigens 2/9/06 “It is only when you give of yourself that you truly give.” K Gibran.

Antigens March 4, Part I Introduction Chapter 1. Overview of the Immune System Chapter 2. Cells and Organs of the Immune System Part II Generation.

Antigens. Objectives What is an antigen? What type of molecules are antigens? Can any particle/foreign body that enters the cell be an antigen? Properties.

Immunogen, antigen, epitope, hapten

Adaptive Immunity  Response occurs within days of the infection  Highly specific  Highly diverse  Memory component  Major cell types involved: T cells,

How Cells of the Immune System “See” and Respond to Antigen

BIOT 307 Kuby, Ch. 3, Antigens March, General Introduction Specificity due to recognition of antigenic determinants or epitopes Epitopes = immunologically.

Adaptive Immunity  Response occurs within days of the infection  Highly specific  Highly diverse  Memory component  Major cell types involved: T cells,

Antibody Fab region bound to a sequential antigen

Overview of the Immune System Immune System Innate (Nonspecific) Cellular Components Humoral Components Adaptive (Specific) Cell- Mediated Humoral (Ab)

Properties and Overview of Immune Responses

Immunology-introduction

Chapter 3 Antigens Substances which can be recognized by Ig of B cells (at F ab sites) and TCR’s of T cells (when accompanied by MHC) B and T cells also.

DEFINITION AND PROPERTIES OF ANTIGEN. Antigen (Ag) - any substance, which is recognized by the mature immune system of a given organism –antigenicity.

Chapter 4 Antigen.

بسم الله الرحمن الرحيم. Antigen Samira Rajaei, MD, PhD. Assistant professor Department of Immunology Tehran University of Medical Sciences.

Cell Signalling and communication between cells..

Antigens, Immunogens, Epitopes, and Haptens. Innate and adaptive immunity:

Innate and Adaptive Immunity

DEFINITION AND PROPERTIES OF ANTIGEN. Antigen (Ag) - any substance, which is recognized by the mature immune system of a given organism –antigenicity.

110/30/2015 Antigens Antigens Hugh B. Fackrell 210/30/2015 ä Assigned Reading ä Content Outline ä Performance Objectives ä Key terms ä Key Concepts ä.

Antigen Receptors of Lymphocytes. Recognition: molecular patterns Recognition : molecular details (antigenic determinants) Innate immunity Aquired immunity.

Antigen IMMUNOLOGY Chen Weilin, Ph.D Institute of immunology, ZJU.

The Immune System: Adaptive Body Defenses Part B

Antigen and Antigenicity Antigen and Antigenicity

1- Antigens Antigen: any substance that stimulate the specific immune response (antibody or a T-cell ) and binds specifically to them Epitope, or, Antigenic.

What is an antigen? An antigen is any substance that elicits an immune response and is then capable of binding to the subsequently produced antibodies.

ANTIGEN Babitha Elias. DEFINITION: Antigen - substance which reacts with specific antibody. Immunogen - substance that can induce immune response. TYPES.

Immunogens, Antigens, and Haptens

Dr. Nabil MTIRAOUI, M.Sc, Ph.D Lecture 7 Antigens and Immunogens Properties and Characteristics.

Fe A. Bartolome, MD, FPASMAP Department of Microbiology Our Lady of Fatima University.

ANTIGENS  Antigen: Any substance reacting with the products of any specific immune response (Ig or T cells)  Immunogen: Any substance capable to induce.

Antigens, Immunogens, Epitopes, and Haptens: Antigen: a molecule or part of a molecule that is recognized by the immune system. The term is associated.

Antigens & Immunogen.

Epitopes: Lymphocytes recog. specific sites on molecules  Ag determinant/epitope With some Ag, B cells recog 1 part; T cells another The recognition process.

Antigen Processing and Presentation, Self MHC Restriction

E. Salehi Tel: Antigens با نام و ياد خدا.

Book, Abul K. Abbas: Basic Immunology

Lecture 2 blood bank PRINCIPLES OF ANTIGENS AND ANTIBODIES By Dr. Dalia Galal Hamouda.

Antigen recognition in adaptive immunity Mechanism of diversity of antigen receptors Maturation and selection of B lymphocytes Maturation and selection.

Immunity. Body Defenses First line - barriers Skin and mucous membranes Flushing action –Antimicrobial substances Lysozyme, acids, salts, normal microbiota.

Chapter 4 Antigen. Definitions of antigen Antigen: non-self substances which can combine with TCR or BCR or Ab and have the potential of inducing immune.

Antigens // are molecules that can be recognized by the immunoglobulin receptor of B cells or by the T-cell receptor when complexed with MHC. immunogens.

Antigens Substances that can be recognized by the immunoglobulin receptor of B cells, or by the T cell receptor when complexed with MHC are called antigens.

Antigens Ali Al Khader, MD Faculty of Medicine

Immunology By Assistant Professor Dr. Ahmed Ali Mohammed.

Foreign agenses, molecules, cells

Humoral immune response

Immunogens and Antigens

Zhijian Cai, Ph.D Institute of immunology, ZJU

MACROMOLECULES A very large molecule consisting of many smaller structural units linked together.

Identify the Four Macromolecules and their Functions

Macromolecules & Enzymes

Antigens Ali Al Khader, MD Faculty of Medicine

مادة المناعة-النظري\ المرحلة الثالثة

Antigen recognition in adaptive immunity

Presentation transcript:

Antigen Presenting Cells Antigens: types and features Principles of antigen recognition by T and B cells Antigen Presenting Cells

ANTIGENS

DEFINITIONS Antigen Immunogen Hapten Carrier Epitope or antigenic determinant

ANTIGEN Molecule that binds antibody or T cell receptor IMUNOGEN antigen that induce immune response

IMMUNOGENICITY Depends on characteristics of the immunogene biological system route of administration

IMUNOGENICITY characteristics of the immunogene Phylogenetic distance Molecular size Chemical composition and heterogeneity proteins > carbohydrates, lipides, nucleic acids Physical appearance particulated > soluble denatured > native

IMUNOGENICITY characteristics of the biological system Genetic bacground species individual Age

IMUNOGENICITY administration of the antigen amount optimal route subcutaneous > intravenous > peroral adjuvant substancee that stimulates immune response to the antigen

HAPTEN small molecule that can not elicit an immune response by itself. It can elicit an immune response only when attached to a large molecule – carrier. CARRIER Macromolecule that enables induction of immune response directed to the attached hapten.

ANTIGENIC DETERIMINANTE or EPITOPE Part of the antigen that binds specific antibody or T-cell receptor Antigenic determinantes of the proteins linear conformational

conformational determinante aminoacid linear determinant

Principles of antigen recognition by T- and B-lymphocytes

Antigens recognized by B-lymphocytes are Proteins (linear and conformational determinants), carbohydrates, nucleic acids etc. Native and processed Soluble and membrane Antigens recognized by T-lymphocytes are Peptides Linear determinants On the cell membrane within groove of self MHC molecule

ANTIGEN-PRESENTING CELLS

Figure 8-14

Nobel prize for medicine 2011 Dendritc cells Ralph Steinman Nobel prize for medicine 2011