ATB: MAKE A NEW LOGBOOK ENTRY “PROTEIN NETWORK PRACTICE 2”

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Presentation transcript:

ATB: MAKE A NEW LOGBOOK ENTRY “PROTEIN NETWORK PRACTICE 2” GET A SHEET FROM THE FRONT COUNTER—1 PER PERSON PLANNER: DESIGN YOUR OWN NETWORK DUE FRIDAY CHECKUP/QUIZ ON FRIDAY LOGBOOK CHECK AT END OF CLASS TODAY IF YOU MISSED THIS MONDAY’S CHECKUP—MAKE IT UP! IT TURNS INTO A ZERO AFTER FRIDAY

Glucose Lactose Lactase Galactose Key: Metabolites Enzyme reactions

Labrador (dog) pigmentation Yellow pigment tyrosinase Tyrosine Dopaquinone TRP-2 Brown pigment TRP-1 Boxes = metabolites Arrows = enzymes that change the metabolites Black pigment

Noradrenaline Dopamine Thyroxine Phenylalanine Homogentisic acid Tyrosine Tyramine Thyroxine Hydroxy- phenylpyruvate Dopa Dopamine Noradrenaline Adrenaline Dopaquinone Melanin Phenylpyruvate Maleyl- acetoacetate Prephenate 1 2 4 3 5 6

Drosophila Eye Color Pigment Network PTERIDINE PIGMENTS OMMOCHROME PIGMENTS Molecule A (colorless) 2-amino-4- hydroxypterdine (BLUE) 1 Molecule B (colorless) 3 xanthopterin (GREEN-BLUE) 2 9 4 tetrahydroiopterin ommochrome pigment (BROWN) isoxanthopterin (VIOLET-BLUE) 7 6 5 biopterin (BLUE) drosopterin (ORANGE) sepiapterin (YELLOW) 8 10 isosepiapterin (YELLOW) Color of fly is result of mixture of all pigments in network In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)

Scarlet White Wild Type Brown

Drosophila Eye Color Pigment Network PTERIDINE PIGMENTS OMMOCHROME PIGMENTS Molecule A (colorless) 2-amino-4- hydroxypterdine (BLUE) 1 Molecule B (colorless) 3 xanthopterin (GREEN-BLUE) 2 9 4 tetrahydroiopterin ommochrome pigment (BROWN) isoxanthopterin (VIOLET-BLUE) 7 6 5 biopterin (BLUE) drosopterin (ORANGE) sepiapterin (YELLOW) 8 10 isosepiapterin (YELLOW) Color of fly is result of mixture of all pigments in network In order to see pigments, they must be transported into specific areas of the eye cells. All the ommochrome and pteridine pigments use the same transport proteins (labeled as protein #10 on the network)

Serotonin Serotonin is a molecule called a neurotransmitter used by cells in the brain to communicate Part of its function is to regulate emotions Abnormally low amounts of serotonin in the brain can cause depression How is serotonin produced, and how can we use our understanding of it to treat depression?

Some enzymes involved in serotonin synthesis Enzyme: AAAD Substrate: 5-HTP Product: serotonin Enzyme: TPH Substrate: tryptophan Product: 5-HTP Enzyme: MAO Substrate: serotonin Product: 5-HIAA 5-HTP 5-HIAA

Draw the enzyme pathway used to build serotonin

5-HTP AAAD Serotonin 5-HTP TPH MAO 5-HIAA Tryptophan 5-HIAA