MOUTH STOMACH Lingual Lipase FFA + DAGs (miniscule amounts)

Slides:

Advertisements

Similar presentations

Lipoprotein Metabolism And Disorders

Advertisements

Lipoproteins Function: Transport of fat soluble substances

Section VI. Lipid Metabolism

LIPOPROTEIN METABOLISM

Metabolism of VLDL Dr. Nikhat Siddiqi.

Cholesterol transport and uptake Dr. Carolyn K. Suzuki 1.

Digestion Mechanical Digestion (mouth, stomach) Chemical Digestion (mouth, stomach, intestines) Absorption (intestines) Assimilation (at each cell in the.

BIOC 460 DR. TISCHLER LECTURE 36 LIPID TRANSPORT.

بسم الله الرحمن الرحيم.

Lipoprotein Structures, Function and Metabolism (1)

 Introduction  Fat is a good source of energy as 1 gm supplies 9.1 calories, which is over double that supplied by carbohydrates or protein.  Dietary.

Lipids: Not Just Fat BIOL 103, Chapter 6-2.

Lipid Digestion. Monogastric Digestion Challenges Lipids are not water soluble Triglycerides too large to be absorbed Digestive solution Triglycerides.

Metabolism of lipids: digestion, absorption, resynthesis in the intestinal wall. 1.

Digestion of Dietary Lipids

H 3 CCCCCCCCCCCCCCC COO H 3 CCCCCCCCCCCCCCC COO H 3 CCCCCCCCCCCCCCC COO H 3 CCCCCCCCCCCCCCC.

Aims 1.Outline the structural diversity of lipids. 2.Examine the biophysical characteristics of lipids. 3Outline the biochemical synthesis of fatty acids,

1 LIPID TRANSPORT Lipoproteins Lipids are transported in the blood as lipoproteins are soluble in water because the surface consists of polar lipids.

The Small Intestine: Absorption 2 Lecture 5 Professor John Peters.

Lipids in the body Functions 1. Membrane component 2. Thermal insulation and mechanical protection 3. Metabolic regulator 4. Energy store -90% of an adipocyte.

Biochemical Aspects of Digestion of Lipids Dr. Amr S. Moustafa.

Lipids – digestion and absorption, blood plasma lipids, lipoproteins Biochemistry II Lecture (J.S.)

Muhammad Azhar Chishti

Metabolism of Dietary Lipids Definition: Lipids are heterogeneous gp of water-insoluble (hydrophobic) organic molecules stored as triacylglycerol in adipose.

Hyperlipidaemia. History  Hypercholestrolemia is an inherited condition and for several years scientists have studied the effects of high cholesterol.

BCH 348: Metabolism-II Dr Nikhat Siddiqi.

LIPIDS Part II: Digestion, Absorption, Transportation & Metabolism.

Cholesterol exogenous (dietary) cholesterol delivered to

10/18/2015 5:36 PM1 LIPID METABOLISM December 2007.

Biochemical Aspects of Digestion of Lipids

ECDA September LIPID DIGESTION  Lipids in the diet are most commonly triglycerides or neutral fats found in both animals and plants. Cholesterols.

Lipid Metabolism Metabolism of dietary lipids.

Lipoproteins The serum lipoproteins are complexes of lipids and specific proteins called "apoproteins". Functions of Lipoproteins Help to transport lipids.

Cellular Biochemistry and metabolism 1 Lecturer of Biochemistry

بسم الله الرحمن الرحيم.

 Main lipids in the blood are the triglycerides and cholesterol.  Insoluble in the water.  Transport in the blood is via lipoproteins.

Digestion and absorption of lipid ط Digestion of lipid, Lingual and gastric lipase ط Pancreatic lipase and formation of micelle ط Role of bile salts and.

Clinical diagnostic biochemistry - 6 Dr. Maha Al-Sedik 2015 CLS 334.

What is absorption? The digested food molecules enter the circulatory system.

Lipids Lipids are heterogeneous group of water insoluble organic molecules. An adult ingests about 60 to 150 g of lipids per day. Dietary fat Composition.

Lipoprotein Structure and Function LP core Triglycerides Cholesterol esters LP surface Phospholipids Proteins Cholesterol Are conjugated proteins, composed.

Biochemical Aspects of Digestion of Lipids Dr. Sumbul Fatma.

LIPIDS Biochemistry Department. Lipid Digestion & absoption.

METABOLISM OF LIPIDS: DIGESTION OF LIPIDS. TRANSPORT FORMS OF LIPIDS.

 The contraction of circular and longitudinal muscle layers of the small intestine mixes the food with enzymes and moves it along the gut  The pancreas.

4. DIGESTION AND ABSORPTION OF LIPIDS. INTRODUCTION Foods are enzymatically digested to prepare them for absorption. During digestion in the gastrointestinal.

Lipid metabolism Digestion and absorption of Lipids.

Lipoprotein Structure, Function, and Metabolism

Lipid metabolism 2016 Lívius Wunderlich.

Lipid Metabolism Metabolism of dietary lipids.

LIPOPROTEINS A to Z.

An Overview of Fatty Acid Metabolism

Biochemical Aspects of Digestion of Lipids

DIGESTION & ABSORPTION OF LIPIDS

Digestion of carbohydrates, proteins & fats - Dietary substrates, enzymes, end-products of digestion.

3. LIPIDS Lecture 3.

Lipid Metabolism Metabolism of dietary lipids.

Questions Fat and Protein.

Advanced Nutrition Lipids 5 MargiAnne Isaia, MD MPH.

بسم الله الرحمن الرحيم.

Metabolism of dietary lipids

Worked Example 24.1 Digesting and Transporting Fats

Delivery of nutrients to cells

Circulating FFAs: origins and lipotoxic effects.

Lipoprotein Metabolism

Lecture 2 BIOCHEMISTRY Gastroenterology & NUTRITION BLOCK (GNT 223)

Presentation transcript:

MOUTH STOMACH Lingual Lipase FFA + DAGs (miniscule amounts) Lipids: Triacylglycerols Cholesterol esters Phospholipids MOUTH FFA + DAGs (small amounts) Lingual Lipase ("acid-stable") 1b Triacylglycerols STOMACH STEP 1: Digestion in the Mouth and Stomach Courtesy of Dr. Marc Tischler

SMALL INTESTINE duodenum/jejunum EXOCRINE PANCREAS CCK-PZ from stomach stimulates secretion FFA from stomach trypsinogen, procolipase, lipase, esterase, HCO3-, proPLA2 Endocrine cell Cholecystokin-pancreozymin (CCK-PZ) via bloodstream Trypsinogen Pancreatic lipase esterase Procolipase Pancreatic ProPLA2 Bile Salt storage SMALL INTESTINE duodenum/jejunum Bile Acid Synthesis Conjuga- tion LIVER GALL BLADDER CCK-PZ causes contraction STEP 2: Enzymatic Digestion in the Duodenum/Jejunum – secretion of zymogens/bile salts Courtesy of Dr. Marc Tischler

Enterohepatic circulation of bile acids SMALL INTESTINE duodenum/jejunum LIVER Enterohepatic circulation of bile acids 3b Portal vein Mixed Micelles 4 FFA, 2MG cholesterol lysolecithin vitamin A Short/medium chain FFA Released bile acids 3b Reabsorbed by ileum Capillaries STEP 3b: Bile Acid Recycling STEP 4: Lipid Absorption Courtesy of Dr. Marc Tischler

To lacteals and thoracic duct (lymphatic system) SMALL INTESTINE duodenum/jejunum 6b To lacteals and thoracic duct (lymphatic system) 6a B48 Coating with apolipoprotein (with TTP) Chylomicron vitamins D, E, K Triacylglycerol transfer protein Triacyl- glycerol Cholesterol ester Phospholipid FFA, 2MG cholesterol lysolecithin vitamin A reesterification 5 ACAT Acyl CoA: cholesterol acyl transferase STEP 5: Re-esterification STEP 6: Chylomicron Assembly and Export Courtesy of Dr. Marc Tischler

chylomicron interacts with lipoprotein lipase removing FFA Lymph system: Chylomicrons to capillaries via lymph INTEST INE Nascent chylo-microns acquire apo CII (C) and E (E) from HDL non-hepatic tissues C E C E C E C E ApoB48 aids with chylo-micron assembly LIVER Chylomicrons carry dietary fatty acids to tissues and the remnants take cholesterol to the liver

chylomicron interacts with lipoprotein lipase removing FFA Lymph system: INTEST INE C E chylomicron acquires apo CII (C) and E (E) from HDL non-hepatic tissues C E C E C E chylomicron remnants lose CII to HDL C E ApoB48 E Liver: apo E receptor takes up remnants to deliver cholesterol LIVER Chylomicrons carry dietary fatty acids to tissues and the remnants take cholesterol to the liver Courtesy of Dr. Marc Tischler