Prions_Stanley B. Prusiner Wen-Chun Shaw Wen-Chun Shaw BTC 575 052 SCIENTIFIC DISCOVERY BTC 575 052 SCIENTIFIC DISCOVERY Dr. Vankley Dr. Vankley.

Slides:

Advertisements

Similar presentations

TAYLOR GOLDBECK Brain Trust Chapters 8 & s- Farmers report sheep with scrapie-like symptoms Creutzfeldt observes a patient with CJD 1918-

Advertisements

Mad Cow Disease 袁聖甯黃竹瑄鄧雯心. What is Mad Cow Disease ? A kind of transmissible spongiform encephalopathies (TSE) Occurs in many mammals, including human.

VIROLOGY – The Study of Viruses Are NOT Small Bacteria Are NOT Living Cells Lack ALL (nearly) enzymes necessary for metabolism and biosynthesis ARE Protein.

1 How did viruses originate? “Viral Mutation Evolved” Media: Pastel on paper WALTER DUPRIEST acanthusarts.org.

Transmissible Spongiform Encephalopathies (Prion disorders)

Prions Fact or Science Fiction?. Stanley Prusiner, 1982 Born in Des Moines, Ia. Suggested that spongiform encephalopathies in animals and humans are caused.

L and D isomers of amino acids. Ionization state as a function of pH.

Mad Cow Disease. Effects of Mad Cow disease Mad cow disease, or bovine spongiform encephalopathy (BSE), is a fatal brain disorder that occurs in cattle.

© Elsevier, 2011.Principles of Molecular Virology Subviral Agents Satellites and viroids – parasites of parasites! Prions - infectious protein molecules.

The Hershesy-chase Experiment

Prion Diseases Microbes and Society Fall What is a Prion? Prion- small proteinaceous infectious particles which resist inactivation by procedures.

Mad Cow Disease The Past History of Mad Cow Disease

Prion biology problem space: Mad cows, itchy sheep and protein structure.

Chapter 20: Viruses and Prokaryotes

Antibiotics, Viruses, and Prions. Bacterial Infections Colonization by harmful bacteria Using the body as resources to grow and reproduce Battled by the.

Diseases Learning Targets and Success Criteria. Infection Learning Target I can explain how viruses, bacteria, fungi and parasites may infect the human.

Transmissible Spongiform Encephalopathies (TSEs) a.k.a. Prion Diseases Transmissible  can be spread Spongiform  resembling a sponge Encephalopathies.

Transmissible Spongiform Encephalopathy Prion Protein Diseases Lisa Kennedy, Dylan Bradford, Madi Hoagland Henefield, Anders Ohman Advisor: Dr. Todd Livdahl.

Prions: Proteins Gone Bad

By : Amirah nu’aimi Sharifah Nurul Hanim TASK 2 – DISCUSS THE EXAMPLE OF PROTEIN FOLDING DISEASE BY STATING THE MECHANISM.

Dr. Stuart Reichler Bio 325. DateSubject Sept 6Introduction, Philosophy of Science, and Strong Inference 11DNA and Gene Structure 13Signal Transduction.

Protein Misfolding Can Have Deadly Consequences Yu Tiantian Li Yihan.

Labs start today, or Thursday Inquiry 1 proposal due 9/9 or 9/13 Class communication via Blackboard, webpage, and/or .

PRIONS Kalina Estrada TA: Yu-Chen Hwang Thursday, 7-8pm.

Prions and Protein Misfolding BICH 107 GENE 105. Kuru Discovered in Papua New Guinea in early 1900's "Trembling with fear" Characterized by headaches,

Viruses Are Noncellular! (Nonliving) (capsid) (at most several hundred genes)

Prion Digestion in the Alimentary Tract Nicholas Toney.

 Foreign Sources of Infection To − Vi Nguyen. Foreign Infection  Preventable environmental source of infection  Remove infectious material, epidemic.

Today: A little more Strong Inference Why are you connected to polar bears? How do we know that anyone else knows anything?

Taylor Goldbeck.  Professor and Head of Neuropathology at Yale- Department of Surgery and Faculty of Neurosciences and Virology  Focuses on dementia.

Scientists Organisms Infectious Agents Earth’s History.

Characterizing and Classifying Viruses, Viroids, and Prions.

The History of Chronic Wasting Disease Dr. Trent Bollinger, CCWHC One World, One Health Symposium Sept. 29, 2004.

Labs start next week (first reflection due)

Beyond Viruses…Beyond Viroids…

THIS IS Phages & Other Viruses Repro- duction HIV & AIDS Diseases & Vaccines Scientists Prions & Viroids.

Prions “Scrapie” “mad cow disease” Nobel Prize 1997

Dr. Stuart Reichler Bio 325. Sample Exam Questions: Some organisms have much more DNA than humans do. Does this mean that they can make a greater diversity.

Microbes and Diseases Chapter 02. CREUTZFELDT-JAKOB DISEASE Prion.

PD – Circuitry changes PD HD Normal. Causes of PD  Genetics  Several identified mutations associated with PD  LRRK2 mutations – some are autosomal.

Studying Biology: Start with a question. –For example: How? Why? When? Where? Etc? How do we get answers? –Strong Inference presents one method (article.

Dr. Stuart Reichler Bio 325. Sample Exam Questions: Some organisms have much more DNA than humans do. Does this mean that they can make a greater diversity.

Dr. Stuart Reichler Bio 311D. DateSubjectTextbook Chapters Jan 14Introduction, Philosophy of Science 16Strong Inferencearticle on webpage 18, 23Meiosis12,

Creutzfeldt-Jakob Disease Atif Chohan & Alex Brown.

The Prion Diseases Stanley B. Prusiner.. Description & History Fifteen years ago I evoked a good deal of skepticism when I proposed that the infectious.

Today’s Lecture: Bringing the disease to YOU! From the 1950s to NOW From Papua New Guinea to the U.S.A.

EARLY DAYS OF GROWTH HORMONE THERAPY: IT PAYS TO TAKE CARE Phil Lowry Leeds University Ciba/Geigy St Bartholomew’s Hospital “Barts”

CLINICAL CORRELATIONS

History of Neurology Stanley B. Prusiner MD 1942-present May 8, 2017

professor in microbiology

Petra Jenišová Veronika Plačková Magdaléna Trojanová

Studying Biology: Start with a question. How do we get answers?

What is Medical Microbiology?

KEY CONCEPT Germs cause many diseases in humans.

Diseases caused by bacteria and viruses

Rabies virus and Prion Dongli Pan

Dr. Stuart Reichler Bio 325.

Studying Biology: Start with a question. How do we get answers?

KEY CONCEPT Infections can be caused in several ways.

Labs start today Inquiry 1 proposal due 9/10 or 9/14

2.1-A Microscopic Look at Life’s Organization

Viruses Bacteria and Biotechnology.

Persistant viral infections of the central nervous system

KEY CONCEPT Infections can be caused in several ways.

Modern Health Problems

Dr. Stuart Reichler Bio 325.

Studying Biology: Start with a question. How do we get answers?

Studying Biology: Start with a question. How do we get answers?

Presentation transcript:

Prions_Stanley B. Prusiner Wen-Chun Shaw Wen-Chun Shaw BTC SCIENTIFIC DISCOVERY BTC SCIENTIFIC DISCOVERY Dr. Vankley Dr. Vankley

Stanley B. Prusiner The Nobel Prize in Physiology or Medicine 1997 For the discovery of "Prions - a new biological principle of infection".

Background Background

Stanley B. Prusiner Born May 28, 1942Born May 28, 1942 Chemistry, University of Pennsylvania (1964)Chemistry, University of Pennsylvania (1964) M.D., University of Pennsylvania, School of Medicine (1968)M.D., University of Pennsylvania, School of Medicine (1968) Internship in Medicine, UCSFInternship in Medicine, UCSF ( )( ) Residency in Neurology, UCSF( )Residency in Neurology, UCSF( )

Since 1968 he has been a professor in neurology, biochemistry, and virology at the University of California in San Francisco, and in Berkeley.Since 1968 he has been a professor in neurology, biochemistry, and virology at the University of California in San Francisco, and in Berkeley.

Department of Neurology, HSE-781, University of California, School of medicine, San Francisco, CA , USADepartment of Neurology, HSE-781, University of California, School of medicine, San Francisco, CA , USA

Prions

Change the concept of pathologyChange the concept of pathology Bacteria Bacteria Fungi Fungi Parasites Parasites Viruses Viruses

Prions are simple proteins that are much smaller than virusesPrions are simple proteins that are much smaller than viruses Prions exist normally as cellular proteins(PrPc) Prions exist normally as cellular proteins(PrPc) PrPc can change its shape to a harmful, disease- causing form (PrPSc) PrPc can change its shape to a harmful, disease- causing form (PrPSc)

PrPSc is very resistant to high temperatures, UV- irradiation and strong degradative enzymes.PrPSc is very resistant to high temperatures, UV- irradiation and strong degradative enzymes.

Slow virus Scarpie virus(sheep) Kuru(highlander in New Guinea) CJD CJD

Diseases

The hippocampus of mice(RML inoculation with RML scarpic prions)

Humans might be infected by prions in 2 ways:Humans might be infected by prions in 2 ways: 1.Acquired infection (diet and following medical procedures such as surgery, growth hormone injections, corneal transplants) i.e. infectious agent implicated. 2.Apparent heredity(sporadic CJD is about 1 /million per year)

Prospect The mystery behind scrapie, kuru, and BSE has finally been unravelled.The mystery behind scrapie, kuru, and BSE has finally been unravelled. Other dementias may have a similar background(Alzheimer's disease)Other dementias may have a similar background(Alzheimer's disease)

Diploma

Reference: ulty/neuro_prusiner.htmlhttp:// ulty/neuro_prusiner.htmlhttp:// ulty/neuro_prusiner.htmlhttp:// ulty/neuro_prusiner.html micro.msb.le.ac.uk/3035/prions.h tmlhttp://www- micro.msb.le.ac.uk/3035/prions.h tml

The End The End